دورية أكاديمية
Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury
| العنوان: | Potential protective effect of astaxanthin on ovary ischemia-reperfusion injury |
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| المؤلفون: | Erdem Toktay, Tugba Tastan, Muhammed Gurbuz, Elif Erbas, Ozlem Demir, Rustem Ugan, Jale Selli |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 25, Iss 2, Pp 173-178 (2022) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | astaxanthin, ischemia, ovary, oxidative stress, rat, reperfusion, Medicine |
| الوصف: | Objective(s): We thought that astaxanthin (ASX) might be a protective agent in oxidative stress damage that develops against ischemia and reperfusion injury in the rat ovary.Materials and Methods: The experimental groups consisted of healthy, I (Ischemia), I+ASX50, I+ASX100, I/R (Ischemia/Reperfusion), I/R+ ASX50, and I/R+ ASX100. Vascular clamps were applied to the ovaries for 3 hr to induce ischemia. For the reperfusion groups, the clamps were opened and blood flow was restored to the ovaries for 3 hr. At the end of the experiment, biochemical, histopathological, and immunohistochemical analyses were made from the tissue samples taken.Results: While MDA levels increased significantly in I and I/R groups, SOD levels decreased. It was found that ASX significantly decreased MDA levels and increased SOD activity in treatment groups depending on the dose. Caspase 3, IL-1 β, and IL-6 expressions were severely increased in ischemia and I/R groups, while the severity of I+ASX50 and I/R+ASX100 immunoreactivity was decreased. While severe hemorrhage areas were observed in I and IR groups, minimal hemorrhage areas were observed in the treatment groups, especially in I/R+ASX100 groups. In addition, inflammatory cells and necrotic cells in the I/R group were not observed in I/R+ASX50 and I/R+ASX100 groups.Conclusion: As a result, it was determined that ASX has a strong protective role against oxidative damage in the treatment of ovarian ischemia-reperfusion injury. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | https://ijbms.mums.ac.ir/article_19630_52482c386086699b27dbed0c1a51c203.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2022.61289.13559 |
| URL الوصول: | https://doaj.org/article/a7968e3d24434195b5cfcab32e4e2fc4 |
| رقم الأكسشن: | edsdoj.7968e3d24434195b5cfcab32e4e2fc4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2022.61289.13559 |