دورية أكاديمية
Strong binding and fluorescence sensing of bisphosphonates by guanidinium-modified calix[5]arene
| العنوان: | Strong binding and fluorescence sensing of bisphosphonates by guanidinium-modified calix[5]arene |
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| المؤلفون: | Jie Gao, Zhe Zheng, Lin Shi, Si-Qi Wu, Hongwei Sun, Dong-Sheng Guo |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1840-1845 (2018) |
| بيانات النشر: | Beilstein-Institut, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | bisphosphonate, calixarene, fluorescence sensing, macrocyclic chemistry, indicator displacement assay, Science, Organic chemistry, QD241-441 |
| الوصف: | Based on the indicator displacement assay (IDA) approach, we herein report the fluorescence “switch-on” sensing and quantitative detection of bisphosphonates (BPs), a class of drugs extensively used in the treatment of patients with various skeletal diseases. Guanidinium-modified calix[5]arene (GC5A) affords strong binding on the micromolar to nanomolar level towards BPs dominantly via multiple salt bridge interactions, which was evaluated by fluorescence competitive titrations. Fluorescent IDA enables the highly sensitive and label-free detection of BPs in buffer solution, and more importantly, in artificial urine. Calibration lines were therefore set up in untreated artificial urine, allowing for quantifying the concentrations of BPs in the biologically relevant low range. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| Relation: | https://doaj.org/toc/1860-5397 |
| DOI: | 10.3762/bjoc.14.157 |
| URL الوصول: | https://doaj.org/article/79b91d4692ca43638519c00289423694 |
| رقم الأكسشن: | edsdoj.79b91d4692ca43638519c00289423694 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
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| DOI: | 10.3762/bjoc.14.157 |