دورية أكاديمية
Role and Dysregulation of miRNA in Patients with Parkinson’s Disease
العنوان: | Role and Dysregulation of miRNA in Patients with Parkinson’s Disease |
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المؤلفون: | Michele Salemi, Giovanna Marchese, Giuseppe Lanza, Filomena I. I. Cosentino, Maria Grazia Salluzzo, Francesca A. Schillaci, Giovanna Maria Ventola, Angela Cordella, Maria Ravo, Raffaele Ferri |
المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 1, p 712 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | Parkinson’s disease, synucleinopathy, microRNA, miRNA, miRNA sequencing, ingenuity pathway analysis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Parkinson’s disease (PD) is a neurodegenerative synucleinopathy that has a not yet fully understood molecular pathomechanism behind it. The role of risk genes regulated by small non-coding RNAs, or microRNAs (miRNAs), has also been highlighted in PD, where they may influence disease progression and comorbidities. In this case-control study, we analyzed miRNAs on peripheral blood mononuclear cells by means of RNA-seq in 30 participants, with the aim of identifying miRNAs differentially expressed in PD compared to age-matched healthy controls. Additionally, we investigated the pathways influenced by differentially expressed miRNAs and assessed whether a specific pathway could potentially be associated with PD susceptibility (enrichment analyses performed using the Ingenuity Pathway Analysis tools). Overall, considering that the upregulation of miRNAs might be related with the downregulation of their messenger RNA targets, and vice versa, we found several putative targets of dysregulated miRNAs (i.e., upregulated: hsa-miR-1275, hsa-miR-23a-5p, hsa-miR-432-5p, hsa-miR-4433b-3p, and hsa-miR-4443; downregulated: hsa-miR-142-5p, hsa-miR-143-3p, hsa-miR-374a-3p, hsa-miR-542-3p, and hsa-miR-99a-5p). An inverse connection between cancer and neurodegeneration, called “inverse comorbidity”, has also been noted, showing that some genes or miRNAs may be expressed oppositely in neurodegenerative disorders and in some cancers. Therefore, it may be reasonable to consider these miRNAs as potential diagnostic markers and outcome measures. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/24/1/712; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms24010712 |
URL الوصول: | https://doaj.org/article/c79f9225fbaa4f45a472f407f670c58a |
رقم الأكسشن: | edsdoj.79f9225fbaa4f45a472f407f670c58a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms24010712 |