دورية أكاديمية
Effect of Glucocorticoid and Melatonin on Immune Function of an Indian Tropical Bird, An and Study
| العنوان: | Effect of Glucocorticoid and Melatonin on Immune Function of an Indian Tropical Bird, An and Study |
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| المؤلفون: | S.S. Singh, S.K. Yadav, C. Haldar |
| المصدر: | European Journal of Inflammation, Vol 8 (2010) |
| بيانات النشر: | SAGE Publishing, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Inverse relationship between circulatory levels of glucocorticoids and melatonin has been reported for most of the vertebrates including human beings. We report the importance of glucocorticoid along with melatonin in avian immune regulation in an Indian tropical bird, Perdicula asiatica with in vivo and in vitro approach. Dexamethasone (30μg/bird/day) treatment of the male birds suppressed the immune activity as judged by the spleen activity (mass, anatomy), circulating total leukocyte, and lymphocyte count, blastogenic response, increased % apoptosis and cytokine (IL-2) production by splenocytes. Melatonin (25μg/100g B.wt./day) treatment increased the above-mentioned immune parameters whereas melatonin together with dexamethasone restored the suppressed immune parameters by dexamethasone to control level. In vitro melatonin (2.5 pM) supplementation to splenocyte cultures restored the dexamethasone (2 μM) suppressed splenocyte proliferation, % apoptosis and IL-2 production. Therefore, melatonin antagonized the suppressive effect of synthetic glucocorticoid on all immune parameters studied in vivo as well as in vitro . Furthermore, exogenous administration of dexamethasone and melatonin treatment altered the circulatory level of corticosterone and melatonin in an inverse manner. It is therefore, suggested that a hormonal trade-off between glucocorticoid and melatonin exists under in vivo and in vitro conditions, being involved in maintenance of the immune function of P. asiatica probably by involving cytokines i.e. IL-2 mediated pathway. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1721-727X 1721727X |
| Relation: | https://doaj.org/toc/1721-727X |
| DOI: | 10.1177/1721727X1000800206 |
| URL الوصول: | https://doaj.org/article/7a3035ff9169451db203b697d966f3bf |
| رقم الأكسشن: | edsdoj.7a3035ff9169451db203b697d966f3bf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1721727X |
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| DOI: | 10.1177/1721727X1000800206 |