دورية أكاديمية
Clinical Phenotype of a First Unprovoked Acute Pulmonary Embolism Associated with Antiphospholipid Antibody Syndrome
| العنوان: | Clinical Phenotype of a First Unprovoked Acute Pulmonary Embolism Associated with Antiphospholipid Antibody Syndrome |
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| المؤلفون: | Yong Sub Na, M.S., Seongsoo Jang, M.D., Seokchan Hong, M.D., Yeon Mok Oh, M.D., Sang Do Lee, M.D., Jae Seung Lee, M.D. |
| المصدر: | Tuberculosis and Respiratory Diseases, Vol 82, Iss 1, Pp 53-61 (2019) |
| بيانات النشر: | The Korean Academy of Tuberculosis and Respiratory Diseases, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | antiphospholipid syndrome, antibodies, antiphospholipid, pulmonary embolism, phenotype, risk factors, Diseases of the respiratory system, RC705-779 |
| الوصف: | Background Antiphospholipid antibody syndrome (APS), an important cause of acquired thrombophilia, is diagnosed when vascular thrombosis or pregnancy morbidity occurs with persistently positive antiphospholipid antibodies (aPL). APS is a risk factor for unprovoked recurrence of pulmonary embolism (PE). Performing laboratory testing for aPL after a first unprovoked acute PE is controversial. We investigated if a specific phenotype existed in patients with unprovoked with acute PE, suggesting the need to evaluate them for APS. Methods We retrospectively reviewed patients with PE and APS (n=24) and those with unprovoked PE with aPL negative (n=44), evaluated 2006–2016 at the Asan Medical Center. We compared patient demographics, clinical manifestations, laboratory findings, and radiological findings between the groups. Results On multivariate logistic regression analysis, two models of independent risk factors for APS-PE were suggested. Model I included hemoptysis (odds ratio [OR], 12.897; 95% confidence interval [CI], 1.025–162.343), low PE severity index (OR, 0.948; 95% CI, 0.917–0.979), and activated partial thromboplastin time (aPTT; OR, 1.166; 95% CI, 1.040–1.307). Model II included age (OR, 0.930; 95% CI, 0.893–0.969) and aPTT (OR, 1.104; 95% CI, 1.000–1.217). Conclusion We conclude that patients with first unprovoked PE with hemoptysis and are age |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1738-3536 2005-6184 |
| Relation: | https://www.e-trd.org/search.php?where=aview&id=10.4046/trd.2018.0045&code=0003TRD&vmode=FULL; https://doaj.org/toc/1738-3536; https://doaj.org/toc/2005-6184 |
| DOI: | 10.4046/trd.2018.0045&code=0003TRD&vmode=FULL |
| URL الوصول: | https://doaj.org/article/7a4be124bdad491fabcccc864e0b7692 |
| رقم الأكسشن: | edsdoj.7a4be124bdad491fabcccc864e0b7692 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17383536 20056184 |
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| DOI: | 10.4046/trd.2018.0045&code=0003TRD&vmode=FULL |