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Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility

التفاصيل البيبلوغرافية
العنوان: Alternative Molecular Tools for the Fight against Infectious Diseases of Small Ruminants: Native Sicilian Sheep Breeds and Maedi-Visna Genetic Susceptibility
المؤلفون: Serena Tumino, Marco Tolone, Paola Galluzzo, Sergio Migliore, Tiziana Sechi, Salvatore Bordonaro, Roberto Puleio, Antonello Carta, Guido Ruggero Loria
المصدر: Animals, Vol 12, Iss 13, p 1630 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Veterinary medicine
LCC:Zoology
مصطلحات موضوعية: TMEM154 gene, maedi-visna, susceptibility, autochthonous sheep, Veterinary medicine, SF600-1100, Zoology, QL1-991
الوصف: Maedi-visna (MV) is a disease caused by small ruminant lentiviruses. It is included in the list of notifiable terrestrial animal diseases due to economic losses and animal welfare harm in the sheep sector. To date, control programs remain the onliest approach to avoiding infection. The allelic variant p.Glu35Lys (E35K) of the TMEM154 gene has been strongly associated with host vulnerability to MV illness. The present study aimed to investigate the association of TMEM154 E35K allele frequencies with MV susceptibility in native Sicilian sheep breeds. More than 400 animals from 14 local sheep were serologically tested and genotyped for the TMEM154 E35K polymorphism. The local breeds displayed different values of MV seroprevalence, with the lowest antibody prevalence in Barbaresca and Pinzirita breeds. TMEM154 protective allele (K35) was less frequent than the risk allele (E35) in Valle del Belìce breed, whereas the other three breeds showed a more balanced alleles distribution. A positive association between seroprevalence and genotype was found in the entire sample set. The risk of infection resulted in more than 3-fold times as high in sheep with EK and EE genotype compared to the KK genotype. Our data could be helpful in establishing selection breeding programs aimed at reducing MV infection in Sicilian sheep farming and encouraging the breeding of native breeds.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-2615
Relation: https://www.mdpi.com/2076-2615/12/13/1630; https://doaj.org/toc/2076-2615
DOI: 10.3390/ani12131630
URL الوصول: https://doaj.org/article/7a75ad389e0645d781f20a2d296b7c4e
رقم الأكسشن: edsdoj.7a75ad389e0645d781f20a2d296b7c4e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20762615
DOI:10.3390/ani12131630