دورية أكاديمية
Contribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle
| العنوان: | Contribution of potassium channels, beta2-adrenergic and histamine H1 receptors in the relaxant effect of baicalein on rat tracheal smooth muscle |
|---|---|
| المؤلفون: | Saeideh Saadat, Javad Boskabadi, Mohammad Hossein Boskabady |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 22, Iss 11, Pp 1347-1352 (2019) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | baicalein, beta2-adrenergic, histamine h1 receptors, relaxation, smooth muscle, trachea, Medicine |
| الوصف: | Objective(s): Baicalein, a compound extracted from a variety of herbs, showed various pharmacological effects. This study evaluated the relaxant effects of baicalein and its underlying molecular mechanisms of action on rat’s isolated tracheal smooth muscle.Materials and Methods: Tracheal smooth muscle were contracted by 10 μM methacholine or 60 mM KCl and the effects of cumulative concentrations of baicalein (5, 10, 20 and 40 mg/ml) and theophylline (0.2, 0.4, 0.6 and 0.8 mM) were evaluated. To examine the possible mechanism(s) of the relaxant effect of baicalein, its effect was also evaluated on incubated tissues with atropine, indomethacin, diltiazem, N(G)-Nitro-L-arginine methyl ester (L-NAME), glibenclamide, propranolol and chlorpheniramine.Results: A concentration-dependent and significant relaxant effect was seen for baicalein in non-incubated tissues contracted by KCl or methacholine (PConclusion: A potent relaxant effect comparable to the effect of theophylline was shown for baicalein, which was probably mediated via inhibition of histamine (H1) receptors, stimulation of beta2-adrenergic receptors and potassium channels activation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/article_13936_ed360ddb8737f76e8cfe845f2c5f2717.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| DOI: | 10.22038/ijbms.2019.36377.8666 |
| URL الوصول: | https://doaj.org/article/ca7a775cdcfc4ad99b3054fdcb9c8fe0 |
| رقم الأكسشن: | edsdoj.7a775cdcfc4ad99b3054fdcb9c8fe0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
|---|---|
| DOI: | 10.22038/ijbms.2019.36377.8666 |