دورية أكاديمية
CD38–Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology
| العنوان: | CD38–Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology |
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| المؤلفون: | Shin Takasawa |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 8, p 4306 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | CD38, cADPR, RYR2, FKBP12.6, pancreatic β cells, CD157, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Calcium (Ca2+) is a ubiquitous and fundamental signaling component that is utilized by cells to regulate a diverse range of cellular functions, such as insulin secretion from pancreatic β-cells of the islets of Langerhans. Cyclic ADP-ribose (cADPR), synthesized from NAD+ by ADP-ribosyl cyclase family proteins, such as the mammalian cluster of differentiation 38 (CD38), is important for intracellular Ca2+ mobilization for cell functioning. cADPR induces Ca2+ release from endoplasmic reticulum via the ryanodine receptor intracellular Ca2+ channel complex, in which the FK506-binding protein 12.6 works as a cADPR-binding regulatory protein. Recently, involvements of the CD38-cADPR signal system in several human diseases and animal models have been reported. This review describes the biochemical and molecular biological basis of the CD38-cADPR signal system and the diseases caused by its abnormalities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/8/4306; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23084306 |
| URL الوصول: | https://doaj.org/article/7abb92571a7a4ab5bb4aec489d523efc |
| رقم الأكسشن: | edsdoj.7abb92571a7a4ab5bb4aec489d523efc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23084306 |