دورية أكاديمية

Antimetastatic Effect of Halichondramide, a Trisoxazole Macrolide from the Marine Sponge Chondrosia corticata, on Human Prostate Cancer Cells via Modulation of Epithelial-to-Mesenchymal Transition

التفاصيل البيبلوغرافية
العنوان: Antimetastatic Effect of Halichondramide, a Trisoxazole Macrolide from the Marine Sponge Chondrosia corticata, on Human Prostate Cancer Cells via Modulation of Epithelial-to-Mesenchymal Transition
المؤلفون: Sang Kook Lee, Jongheon Shin, Ju-eun Jeon, Gi Dae Kim, Yoonho Shin
المصدر: Marine Drugs, Vol 11, Iss 7, Pp 2472-2485 (2013)
بيانات النشر: MDPI AG, 2013.
سنة النشر: 2013
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: halichondramide (HCA), antimetastasis, PC3 cells, PRL-3, MMPs, Biology (General), QH301-705.5
الوصف: Halichondramide (HCA), a trisoxazole-containing macrolide isolated from the marine sponge Chondrosia corticata has been shown to exhibit cytotoxicity and antifungal activities. In our previous study, HCA was also found to exhibit antiproliferative activity against a variety of cancer cells. However, the precise mechanism of action of HCA in the antitumor activity remains to be elucidated. In the present study, we identified the antimetastatic activity of HCA in the highly metastatic PC3 human prostate cancer cells. HCA showed potent growth inhibitory activity of the PC3 cells with an IC50 value of 0.81 µM. Further analysis revealed that HCA suppressed the expression of a potential metastatic biomarker, phosphatase of regenerating liver-3 (PRL-3), in PC3 cells. The suppression of PRL-3 by HCA sequentially down-regulates the expression of phosphoinositide 3-kinase (PI3K) subunits p85 and p110. The antimetastatic effect of HCA was also correlated with the down-regulation of matrix metalloproteases (MMPs) and the modulation of cadherin switches N-cadherin and E-cadherin. In addition, HCA also effectively suppressed the migration and invasion of PC3 cells. These findings suggest that halichondramide might serve as a potential inhibitor of tumor cell metastasis with the modulation of PRL-3.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1660-3397
Relation: http://www.mdpi.com/1660-3397/11/7/2472; https://doaj.org/toc/1660-3397
DOI: 10.3390/md11072472
URL الوصول: https://doaj.org/article/aa7ae8d4b2954bbe926b17914465e5fd
رقم الأكسشن: edsdoj.7ae8d4b2954bbe926b17914465e5fd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16603397
DOI:10.3390/md11072472