دورية أكاديمية
أعرض في EDS

Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume.

التفاصيل البيبلوغرافية
العنوان: Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume.
المؤلفون: Manish S Dalwani, Mary Agnes McMahon, Susan K Mikulich-Gilbertson, Susan E Young, Michael F Regner, Kristen M Raymond, Shannon K McWilliams, Marie T Banich, Jody L Tanabe, Thomas J Crowley, Joseph T Sakai
المصدر: PLoS ONE, Vol 10, Iss 5, p e0126368 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Structural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here we compare gray matter volume between female adolescents with severe substance and conduct problems and female healthy controls of similar ages.Female adolescents with severe substance and conduct problems will show significantly less gray matter volume in frontal regions critical to inhibition (i.e. dorsolateral prefrontal cortex and ventrolateral prefrontal cortex), conflict processing (i.e., anterior cingulate), valuation of expected outcomes (i.e., medial orbitofrontal cortex) and the dopamine reward system (i.e. striatum).We conducted whole-brain voxel-based morphometric comparison of structural MR images of 22 patients (14-18 years) with severe substance and conduct problems and 21 controls of similar age using statistical parametric mapping (SPM) and voxel-based morphometric (VBM8) toolbox. We tested group differences in regional gray matter volume with analyses of covariance, adjusting for age and IQ at p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4441424?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0126368
URL الوصول: https://doaj.org/article/c7aed366849640dc9994d6561ee9bcbd
رقم الأكسشن: edsdoj.7aed366849640dc9994d6561ee9bcbd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0126368