دورية أكاديمية
The Role of α-Synuclein Oligomers in Parkinson’s Disease
| العنوان: | The Role of α-Synuclein Oligomers in Parkinson’s Disease |
|---|---|
| المؤلفون: | Xiao-yu Du, Xi-xiu Xie, Rui-tian Liu |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 22, p 8645 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | α-synuclein, Parkinson’s disease, oligomers, structure, toxicity, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | α-synuclein (α-syn) is a protein associated with the pathogenesis of Parkinson’s disease (PD), the second most common neurodegeneration disease with no effective treatment. However, how α-syn drives the pathology of PD remains elusive. Recent studies suggest that α-syn oligomers are the primary cause of neurotoxicity and play a critical role in PD. In this review, we discuss the process of α-syn oligomers formation and the current understanding of the structures of oligomers. We also describe seed and propagation effects of oligomeric forms of α-syn. Then, we summarize the mechanism by which α-syn oligomers exert neurotoxicity and promote neurodegeneration, including mitochondrial dysfunction, endoplasmic reticulum stress, proteostasis dysregulation, synaptic impairment, cell apoptosis and neuroinflammation. Finally, we investigate treatment regimens targeting α-syn oligomers at present. Further research is needed to understand the structure and toxicity mechanism of different types of oligomers, so as to provide theoretical basis for the treatment of PD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/21/22/8645; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms21228645 |
| URL الوصول: | https://doaj.org/article/7b1737689bac4f6ba52fbc5118d4dc65 |
| رقم الأكسشن: | edsdoj.7b1737689bac4f6ba52fbc5118d4dc65 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms21228645 |