دورية أكاديمية
Effect of Recombinant Vesicular Stomatitis Virus–Zaire Ebola Virus Vaccination on Ebola Virus Disease Illness and Death, Democratic Republic of the Congo
| العنوان: | Effect of Recombinant Vesicular Stomatitis Virus–Zaire Ebola Virus Vaccination on Ebola Virus Disease Illness and Death, Democratic Republic of the Congo |
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| المؤلفون: | Neil Rupani, Mbong Eta Ngole, J. Austin Lee, Adam R. Aluisio, Monique Gainey, Shiromi M. Perera, Lina Kashibura Ntamwinja, Ruffin Mbusa Matafali, Rigo Fraterne Muhayangabo, Fiston Nganga Makoyi, Razia Laghari, Adam C. Levine, Alexis S. Kearney |
| المصدر: | Emerging Infectious Diseases, Vol 28, Iss 6, Pp 1180-1188 (2022) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Ebola virus, recombinant vesicular stomatitis virus–Zaire Ebola virus, rVSV-ZEBOV, viruses, hemorrhagic fever, Ebola, Medicine, Infectious and parasitic diseases, RC109-216 |
| الوصف: | We conducted a retrospective cohort study to assess the effect vaccination with the live-attenuated recombinant vesicular stomatitis virus–Zaire Ebola virus vaccine had on deaths among patients who had laboratory-confirmed Ebola virus disease (EVD). We included EVD-positive patients coming to an Ebola Treatment Center in eastern Democratic Republic of the Congo during 2018–2020. Overall, 25% of patients vaccinated before symptom onset died compared with 63% of unvaccinated patients. Vaccinated patients reported fewer EVD-associated symptoms, had reduced time to clearance of viral load, and had reduced length of stay at the Ebola Treatment Center. After controlling for confounders, vaccination was strongly associated with decreased deaths. Reduction in deaths was not affected by timing of vaccination before or after EVD exposure. These findings support use of preexposure and postexposure recombinant vesicular stomatitis virus–Zaire Ebola virus vaccine as an intervention associated with improved death rates, illness, and recovery time among patients with EVD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/28/6/21-2223_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2806.212223 |
| URL الوصول: | https://doaj.org/article/7b2216c572b44a10bc055cb0800a0a3b |
| رقم الأكسشن: | edsdoj.7b2216c572b44a10bc055cb0800a0a3b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10806040 10806059 |
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| DOI: | 10.3201/eid2806.212223 |