دورية أكاديمية
Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth
العنوان: | Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth |
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المؤلفون: | Marianne Strazza, Emily K. Moore, Kieran Adam, Inbar Azoulay-Alfaguter, Adam Mor |
المصدر: | Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 380-390 (2022) |
بيانات النشر: | Elsevier, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Genetics LCC:Cytology |
مصطلحات موضوعية: | PAG, PD-1, T cells, MC38, checkpoint inhibitor, antibody, Genetics, QH426-470, Cytology, QH573-671 |
الوصف: | The transmembrane adaptor phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG) is phosphorylated in T cells downstream of PD-1 signaling and contributes to the resulting functional inhibition of multiple cellular processes. Furthermore, PAG expression is negatively correlated with survival in multiple human tumors and is a driver of murine tumor growth and immune evasion. Here we develop an antibody that targets the extracellular domain of human PAG, with cross-reactivity to murine PAG. We demonstrate that this antibody binds to extracellular PAG on intact cells and affects T cell activation. Finally, we show that administration of anti-PAG monoclonal antibody in combination with anti-PD-1 antibody to mice bearing MC38 tumors limited tumor growth and enhanced T cell infiltration to tumors. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2329-0501 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2329050122001541; https://doaj.org/toc/2329-0501 |
DOI: | 10.1016/j.omtm.2022.10.012 |
URL الوصول: | https://doaj.org/article/7b309f1b92964a77bed8276d7e43199e |
رقم الأكسشن: | edsdoj.7b309f1b92964a77bed8276d7e43199e |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 23290501 |
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DOI: | 10.1016/j.omtm.2022.10.012 |