دورية أكاديمية
Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth
| العنوان: | Neutralization of the adaptor protein PAG by monoclonal antibody limits murine tumor growth |
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| المؤلفون: | Marianne Strazza, Emily K. Moore, Kieran Adam, Inbar Azoulay-Alfaguter, Adam Mor |
| المصدر: | Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 380-390 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Genetics LCC:Cytology |
| مصطلحات موضوعية: | PAG, PD-1, T cells, MC38, checkpoint inhibitor, antibody, Genetics, QH426-470, Cytology, QH573-671 |
| الوصف: | The transmembrane adaptor phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG) is phosphorylated in T cells downstream of PD-1 signaling and contributes to the resulting functional inhibition of multiple cellular processes. Furthermore, PAG expression is negatively correlated with survival in multiple human tumors and is a driver of murine tumor growth and immune evasion. Here we develop an antibody that targets the extracellular domain of human PAG, with cross-reactivity to murine PAG. We demonstrate that this antibody binds to extracellular PAG on intact cells and affects T cell activation. Finally, we show that administration of anti-PAG monoclonal antibody in combination with anti-PD-1 antibody to mice bearing MC38 tumors limited tumor growth and enhanced T cell infiltration to tumors. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2329-0501 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2329050122001541; https://doaj.org/toc/2329-0501 |
| DOI: | 10.1016/j.omtm.2022.10.012 |
| URL الوصول: | https://doaj.org/article/7b309f1b92964a77bed8276d7e43199e |
| رقم الأكسشن: | edsdoj.7b309f1b92964a77bed8276d7e43199e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23290501 |
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| DOI: | 10.1016/j.omtm.2022.10.012 |