التفاصيل البيبلوغرافية
العنوان:
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells
المؤلفون:
Xiao Gao , Qingwei Wang , Ying Wang , Jiang Liu , Shuang Liu , Jian Liu , Xingli Zhou , Li Zhou , Hui Chen , Linian Pan , Jiwei Chen , Da Wang , Qing Zhang , Shihui Shen , Yu Xiao , Zhipeng Wu , Yiyun Cheng , Geng Chen , Syeda Kubra , Jun Qin , Lan Huang , Pei Zhang , Chuangui Wang , Robb E. Moses , David M. Lonard , Bert W. O’ Malley , Fuad Fares , Bianhong Zhang , Xiaotao Li , Lei Li , Jianru Xiao
المصدر:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
بيانات النشر:
Nature Portfolio, 2020.
سنة النشر:
2020
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
How the REGγ-proteasome pathway is regulated during the cell cycle or genotoxic insults remains unclear. Here, the authors show that NIP30 acts as a molecular switch to regulate the REGγ-proteasome activity and may provide an approach to combat drug-resistant tumours lacking functional p53.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-020-17667-7
URL الوصول:
https://doaj.org/article/7b5a15238e124a499bbec73fb760c725
رقم الأكسشن:
edsdoj.7b5a15238e124a499bbec73fb760c725
قاعدة البيانات:
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