دورية أكاديمية
Matrin3 (MATR3) Expression Is Associated with Hemophagocytosis
| العنوان: | Matrin3 (MATR3) Expression Is Associated with Hemophagocytosis |
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| المؤلفون: | Wen-Chi Yang, Sheng-Fung Lin, Shih-Chi Wu, Chih-Wen Shu |
| المصدر: | Biomedicines, Vol 10, Iss 9, p 2161 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | hemophagocytosis, NF-κB, MATR3, Epstein–Barr virus, necrosis, latex beads, Biology (General), QH301-705.5 |
| الوصف: | Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by prolonged fever, cytopenia, hepatosplenomegaly, and hemophagocytosis. This occurs as a result of activated macrophages and impaired function of natural killer cells and/or cytotoxic T lymphocytes. The NF-κB pathway plays a crucial role in hyperinflammation. Matrin3 (MATR3) is a nuclear RNA/DNA-binding protein that plays multiple roles in the regulation of gene expression. We enroll 62 patients diagnosed with secondary HLH and hemophagocytosis. Peripheral blood (PB) from 25 patients and 30 healthy volunteers and good quality bone marrow (BM) samples from 47 patients are collected and used for analysis. Clinical parameters, including age, sex, etiology, ferritin, fibrinogen, triglyceride, and viral infection status, had no association with survival prediction. Patients with downregulation of NF-κB and MATR3mRNA expression in the BM had a higher mortality rate. MATR3mRNA expression in PB was lower in patients compared to that in healthy volunteers. We use shRNA-MATR3-KD-THP1 cells to determine the efficacy of phagocytosis. We note that shRNA-MATR3-KD-THP1 cells had a higher phagocytic effect on necrotic Jurkat E6 cells and carboxylate modified polystyrene latex beads. Herein, we provide evidence of a new marker for clinical translation that can serve as a potential treatment target for secondary HLH. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 10092161 2227-9059 |
| Relation: | https://www.mdpi.com/2227-9059/10/9/2161; https://doaj.org/toc/2227-9059 |
| DOI: | 10.3390/biomedicines10092161 |
| URL الوصول: | https://doaj.org/article/7b66a9fa428f4d5f88dcbb08d496afe5 |
| رقم الأكسشن: | edsdoj.7b66a9fa428f4d5f88dcbb08d496afe5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10092161 22279059 |
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| DOI: | 10.3390/biomedicines10092161 |