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Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema

التفاصيل البيبلوغرافية
العنوان: Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema
المؤلفون: Jian-Wei Wang, Chuan-Hong Jie, Yong-Jian Tao, Ning Meng, Yuan-Chun Hu, Zheng-Zheng Wu, Wen-Jing Cai, Xi-Mei Gong
المصدر: International Journal of Ophthalmology, Vol 11, Iss 7, Pp 1185-1191 (2018)
بيانات النشر: Press of International Journal of Ophthalmology (IJO PRESS), 2018.
سنة النشر: 2018
المجموعة: LCC:Ophthalmology
مصطلحات موضوعية: 1191, diabetic retinopathy/complications, macular edema, visual fields, retina/physiopathology, optical coherence tomography, Ophthalmology, RE1-994
الوصف: AIM: To respectively evaluate macular morphological features and functional parameters by using spectral-domain optical coherence tomography (SD-OCT) and macular integrity assessment (MAIA) in patients with diabetic macular edema (DME). METHODS: This prospective, non-controlled, open study included 61 eyes of 38 consecutive patients with DME. All patients underwent best-corrected visual acuity (BCVA) measurement, MAIA microperimetry, and SD-OCT. DME morphology, including central retinal thickness (CRT) and central retinal volume (CRV); integrity of the external limiting membrane (ELM) and photoreceptor inner segment/outer segment (IS/OS) junction; and the deposition of hard macular exudates were assessed within a 1000-μm central subfield area. MAIA microperimetry parameters evaluated were average threshold (AT)-retinal sensitivity, macular integrity index (MI), fixation points within a circle of radius 1° (P1) and 2° (P2), and bivariate contour ellipse area considering 63% and 95% of the fixation points (A63 and A95, respectively). RESULTS: MI was significantly higher in eyes with disrupted ELM or IS/OS, compared with eyes with intact ELM and IS/OS. Values of BCVA (logMAR), total AT, AT within 1000-μm diameter, P2, A63, A95, and CRT were significantly worse in eyes with disrupted IS/OS, compared with eyes with intact IS/OS. The values of BCVA (logMAR), AT within 1000-μm diameter, and CRT were significantly worse in eyes with disrupted ELM, compared with eyes with intact ELM. These parameters were not significantly different between eyes with or without hard macular exudate deposition. CRV was not significantly different in the presence or absence of the integrity of ELM, IS/OS, or deposition of hard macular exudates. At the center, nasal and temporal sectors of the fovea, significant negative correlations were observed between retinal thickness and AT of the corresponding area. At the inferior and superior sectors of the fovea, no correlations were observed between retinal thickness and AT of the corresponding area. In the intact IS/OS group, significant negative correlations were observed between CRT and central AT. There was no correlation between retinal sensitivity and thickness when the IS/OS layer was disrupted. Multiple linear regression analyses revealed that IS/OS integrity was an independent factor affecting MI. CONCLUSION: Functional (BCVA and visual field) and morphological parameters (retinal thickness) were significantly associated with an intact IS/OS. Local photoreceptor integrity was a strong predictor of local visual function throughout the retina. MI revealed the functional status in DME, reflecting the IS/OS juction status in the macula.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2222-3959
2227-4898
Relation: http://www.ijo.cn/en_publish/2018/7/20180718.pdf; https://doaj.org/toc/2222-3959; https://doaj.org/toc/2227-4898
DOI: 10.18240/ijo.2018.07.18
URL الوصول: https://doaj.org/article/7bccd948d413431bb5e61bd6fd7ff3e7
رقم الأكسشن: edsdoj.7bccd948d413431bb5e61bd6fd7ff3e7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22223959
22274898
DOI:10.18240/ijo.2018.07.18