دورية أكاديمية
Molecular coordination of Staphylococcus aureus cell division
| العنوان: | Molecular coordination of Staphylococcus aureus cell division |
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| المؤلفون: | Victoria A Lund, Katarzyna Wacnik, Robert D Turner, Bryony E Cotterell, Christa G Walther, Samuel J Fenn, Fabian Grein, Adam JM Wollman, Mark C Leake, Nicolas Olivier, Ashley Cadby, Stéphane Mesnage, Simon Jones, Simon J Foster |
| المصدر: | eLife, Vol 7 (2018) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | Staphylococcus aureus, Peptidoglycan, Division, Cell wall, Divisome, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen Staphylococcus aureus is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/32057; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.32057 |
| URL الوصول: | https://doaj.org/article/e7bf4c1659a047a0972561a7ebc7c0c9 |
| رقم الأكسشن: | edsdoj.7bf4c1659a047a0972561a7ebc7c0c9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.32057 |