دورية أكاديمية
Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden
| العنوان: | Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden |
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| المؤلفون: | Mi-Yeon Eun, Ha‑Na Song, Jong‑Un Choi, Hwan‑Ho Cho, Hyung Jun Kim, Jong-Won Chung, Tae-Jin Song, Jin-Man Jung, Oh‑Young Bang, Gyeong‑Moon Kim, Hyunjin Park, David S. Liebeskind, Woo-Keun Seo |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Tortuosity, Intracranial atherosclerosis, Stroke, Medicine, Science |
| الوصف: | Abstract The effect of arterial tortuosity on intracranial atherosclerosis (ICAS) is not well understood. This study aimed to evaluate the effect of global intracranial arterial tortuosity on intracranial atherosclerotic burden in patients with ischemic stroke. We included patients with acute ischemic stroke who underwent magnetic resonance angiography (MRA) and classified them into three groups according to the ICAS burden. Global tortuosity index (GTI) was defined as the standardized mean curvature of the entire intracranial arteries, measured by in-house vessel analysis software. Of the 516 patients included, 274 patients had no ICAS, 140 patients had a low ICAS burden, and 102 patients had a high ICAS burden. GTI increased with higher ICAS burden. After adjustment for age, sex, vascular risk factors, and standardized mean arterial area, GTI was independently associated with ICAS burden (adjusted odds ratio [adjusted OR] 1.33; 95% confidence interval [CI] 1.09–1.62). The degree of association increased when the arterial tortuosity was analyzed limited to the basal arteries (adjusted OR 1.48; 95% CI 1.22–1.81). We demonstrated that GTI is associated with ICAS burden in patients with ischemic stroke, suggesting a role for global arterial tortuosity in ICAS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-61527-z |
| URL الوصول: | https://doaj.org/article/7c138b1c75274409b4f9051e6c681094 |
| رقم الأكسشن: | edsdoj.7c138b1c75274409b4f9051e6c681094 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-61527-z |