دورية أكاديمية

Urinary enzymes and microalbuminuria as biomarkers of renal dysfunction after contrast administration

التفاصيل البيبلوغرافية
العنوان: Urinary enzymes and microalbuminuria as biomarkers of renal dysfunction after contrast administration
المؤلفون: Ashalatha VL, Bitla AR, Suchitra MM, Rajasekhar D, Siva Kumar V, Lakshmi AY, Srinivasa Rao PVLN
المصدر: Journal of Clinical and Scientific Research, Vol 4, Iss 4, Pp 256-265 (2015)
بيانات النشر: Wolters Kluwer Medknow Publications, 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
مصطلحات موضوعية: Biomarkers, Beta N-Acetyl-D-Glucosaminidase, Coronary Angiography, Medicine
الوصف: Background: Contrast-induced nephropathy (CIN) is a common complication after administration of intravenous iodinated contrast media. The present study evaluated the usefulness of urinary beta-N-acetyl D-glucosaminidase (uNAG), alkaline phosphatase (u-ALP) and lactate dehydrogenase (u-LDH) as markers of tubular injury and urinary microalbumin (u-MA) as a marker of glomerular injury for early diagnosis of CIN in patients undergoing coronary interventions. Methods: One hundred and twenty patients scheduled for elective coronary angiography (CAG), with or without angioplasty with baseline serum creatinine less than 1.2 mg/dL were recruited. Serum creatinine, u-NAG, u-ALP, uLDH and u-MA were analyzed at 0, 4 and 24 hours after administration of low-osmolal, non-ionic contrast medium. Results: CIN developed in 27 (22.5%) patients. A significant increase in u-ALP, u-LDH and in u-MA was seen in both CIN and non-CIN groups. However, no significant difference was observed in these markers between the two groups. A significant increase in u-NAG was observed only in the CIN group. Conclusions: Low osmolal, non-ionic contrast medium produced toxic insult to the glomeruli as well as renal tubules even in patients with normal baseline renal function and u-NAG can differentiate patients with CIN.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2277-5706
2277-8357
Relation: http://svimstpt.ap.nic.in/jcsr/Oct-dec15_files/1oa15.pdf; https://doaj.org/toc/2277-5706; https://doaj.org/toc/2277-8357
DOI: 10.15380/2277-5706.JCSR.14.055
URL الوصول: https://doaj.org/article/da7c1fa329a5424f861f462a781139b0
رقم الأكسشن: edsdoj.7c1fa329a5424f861f462a781139b0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22775706
22778357
DOI:10.15380/2277-5706.JCSR.14.055