دورية أكاديمية
Landscape of Hopx expression in cells of the immune system
| العنوان: | Landscape of Hopx expression in cells of the immune system |
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| المؤلفون: | Jessica Bourque, Adeleye Opejin, Alexey Surnov, Courtney A. Iberg, Cindy Gross, Rajan Jain, Jonathan A. Epstein, Daniel Hawiger |
| المصدر: | Heliyon, Vol 7, Iss 11, Pp e08311- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Hopx, Immune cells, scRNA-seq, Mice, Flow cytometry, Expression, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Homeodomain only protein (Hopx) is a regulator of cell differentiation and function, and it has also emerged as a crucial marker of specific developmental and differentiation potentials. Hopx expression and functions have been identified in some stem cells, tumors, and in certain immune cells. However, expression of Hopx in immune cells remains insufficiently characterized. Here we report a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions. By utilizing single-cell RNA sequencing (scRNA-seq) and flow cytometric analysis, we characterize a constitutive expression of Hopx in specific subsets of CD4+ and CD8+ T cells and B cells, as well as natural killer (NK), NKT, and myeloid cells. In contrast, Hopx expression is not present in conventional dendritic cells and eosinophils. The utility of identifying expression of Hopx in immune cells may prove vital in delineating specific roles of Hopx under multiple immune conditions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844021024142; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2021.e08311 |
| URL الوصول: | https://doaj.org/article/c7c4ba982f4e448781ed717303b4b161 |
| رقم الأكسشن: | edsdoj.7c4ba982f4e448781ed717303b4b161 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2021.e08311 |