دورية أكاديمية
أعرض في EDS

Molecular epidemiology and clinical impact of Klebsiella spp. causing bloodstream infections in Hong KongResearch in context

التفاصيل البيبلوغرافية
العنوان: Molecular epidemiology and clinical impact of Klebsiella spp. causing bloodstream infections in Hong KongResearch in context
المؤلفون: Xuemei Yang, Man-Yee Man, Heng Heng, Bill Kwan-Wai Chan, Qiao Hu, Edward Wai-Chi Chan, Hoi-Ping Shum, Sheng Chen
المصدر: EBioMedicine, Vol 101, Iss , Pp 104998- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Medicine (General)
مصطلحات موضوعية: Klebsiella pneumoniae, Bloodstream infections, Epidemiology, Risk factors, Mortality rate, Medicine, Medicine (General), R5-920
الوصف: Summary: Background: The epidemiological features of the Klebsiella pneumoniae causing bloodstream infections in Hong Kong and their potential threats to human health remained unknown. Methods: K. pneumoniae strains collected from four hospitals in Hong Kong during the period of 2009–2018 were subjected to molecular typing, string test, antimicrobial susceptibility testing, whole genome sequencing and analysis. Clinical data of patients from whom these strains were isolated were analyzed retrospectively using univariate and multivariate logistic regression approaches. Findings: The 240 Klebsiella spp. strains belonged to 123 different STs and 63 different capsule loci (KLs), with KL1 and KL2 being the major type. 86 out of 212 BSI-KP (40.6%) carried at least one of the virulence genes iuc, iro, rmpA or rmpA2. Virulence plasmid correlated well with the string test positive result, yet 8 strains without rmp genes were also hypermucoviscous, which was due to wzc mutation. The mortality rate of bloodstream infection patients was 43.0%. Univariant analysis showed that factors including renal replacement therapy (FDR adjusted p = 0.0007), mechanical ventilation (FDR adjusted p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-3964
Relation: http://www.sciencedirect.com/science/article/pii/S2352396424000331; https://doaj.org/toc/2352-3964
DOI: 10.1016/j.ebiom.2024.104998
URL الوصول: https://doaj.org/article/7c5617d16b734c64b1d3c312d7bdd914
رقم الأكسشن: edsdoj.7c5617d16b734c64b1d3c312d7bdd914
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23523964
DOI:10.1016/j.ebiom.2024.104998