دورية أكاديمية
544 Interleukin-6 protects renal dysfunction in mouse models of hypertension and salt-sensitive hypertension
| العنوان: | 544 Interleukin-6 protects renal dysfunction in mouse models of hypertension and salt-sensitive hypertension |
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| المؤلفون: | Mark D. Hatcher, Rong Duan, Dexter L. Lee |
| المصدر: | Journal of Clinical and Translational Science, Vol 8, Pp 162-162 (2024) |
| بيانات النشر: | Cambridge University Press, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | OBJECTIVES/GOALS: We are investigating the role of IL-6 in regulating renal function by measuring mean arterial pressure (MAP), renal plasma flow (RPF) and glomerular filtration rate (GFR) in wild type (WT) and IL-6-knockout (KO) mice in established mouse models of angiotensin II (AII)-dependent- hypertension and -salt-sensitive hypertension. METHODS/STUDY POPULATION: Twelve-week-old male WT and KO mice on the C57BL6 background strain were infused with vehicle (V; saline) or angiotensin II (AII; 200 ng/kg/min) for 12-14 days. Half of the AII-treatment groups were maintained on a high salt (HS; 6% NaCl) diet for the duration of the experiment, while the other half of the AII treatment groups and both vehicle groups were fed normal rat chow. MAP was continuously measured by a fluid filled catheter in conscious mice for the duration of the experiment. RPF and GFR were measured on days 12-14 in anesthetized mice by the para-aminohippurate, and fluorescein isothiocynate-Inulin techniques, respectively. All data were analyzed by 2-way ANOVA; *p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2059-8661 70422664 |
| Relation: | https://www.cambridge.org/core/product/identifier/S2059866124004643/type/journal_article; https://doaj.org/toc/2059-8661 |
| DOI: | 10.1017/cts.2024.464 |
| URL الوصول: | https://doaj.org/article/a7c70422664a48b3b46ef24f7ce89517 |
| رقم الأكسشن: | edsdoj.7c70422664a48b3b46ef24f7ce89517 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20598661 70422664 |
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| DOI: | 10.1017/cts.2024.464 |