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Serum IL-28A/IFN-λ2 is linked to disease severity of COVID-19

التفاصيل البيبلوغرافية
العنوان: Serum IL-28A/IFN-λ2 is linked to disease severity of COVID-19
المؤلفون: Yosuke Fukuda, Tetsuya Homma, Hideki Inoue, Yuiko Goto, Yoko Sato, Hitoshi Ikeda, Chisato Onitsuka, Hiroki Sato, Kaho Akimoto, Takaya Ebato, Hiromitsu Suganuma, Tomoko Kawahara, Hatsuko Mikuni, Yoshitaka Uchida, Shintaro Suzuki, Akihiko Tanaka, Hironori Sagara
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Type III interferons (IFNs) play an important role in respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to determine whether the expression of serum type III IFNs predicted disease severity among patients with the coronavirus disease (COVID-19). A retrospective cohort study was conducted of patients admitted to a single hospital between March 21, 2020, and March 31, 2021. Patients were divided into mild to moderate I (MM) and moderate II to severe (MS) groups based on the COVID-19 severity classification developed by the Japanese Ministry of Health, Labor and Welfare. A total of 257 patients were included in the analysis. Human interleukin-28A (IL-28A/IFN-λ2) expression was significantly lower, and interleukin (IL)-6 expression was significantly higher in the MS group than in the MM group (both p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-022-09544-8
URL الوصول: https://doaj.org/article/a7c80423ad324eaf97c5ba8c96452bb9
رقم الأكسشن: edsdoj.7c80423ad324eaf97c5ba8c96452bb9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-022-09544-8