دورية أكاديمية
Phytochemical Screening and Antidiabetic Activity of Aqueous Extract of Evolvulus Alsinoides Leaves: An In Vitro and In Silico Study
| العنوان: | Phytochemical Screening and Antidiabetic Activity of Aqueous Extract of Evolvulus Alsinoides Leaves: An In Vitro and In Silico Study |
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| المؤلفون: | Mukundh S Tarun, Veeraraghavan Vishnu Priya, Ponnusamy Bhuvaneswari |
| المصدر: | Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1246-1248 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pharmacy and materia medica LCC:Analytical chemistry |
| مصطلحات موضوعية: | evolvulus alsinoides, health-care, in silico assay, type – 2 diabetes, Pharmacy and materia medica, RS1-441, Analytical chemistry, QD71-142 |
| الوصف: | BackgroundNowadays, diabetes mellitus has become common worldwide due to changes in lifestyle, sedentary life, alterations in food habits, and other genetic and environmental factors. It is necessary to create awareness about the growing pandemic. AimTo evaluate the antidiabetic potential of Evolvulus alsinoides. MethodsIn vitro α-amylase inhibition and α-glucosidase inhibition activity. Molecular docking analysis. ResultsThe plant is rich in naturally occurring phytocompound. The results of the study showed that E. alsinoides has the potential to inhibit the activity of alpha-amylase and alpha-glucosidase. Moreover, this result was validated using in silico molecular docking studies that showed a good binding affinity of one of the major phytocompound, caffeic acid, with molecules in the insulin signaling cascade. ConclusionE. alsinoides has a potent antidiabetic activity and can be further employed in animal and human studies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0976-4879 0975-7406 |
| Relation: | https://journals.lww.com/10.4103/jpbs.jpbs_585_23; https://doaj.org/toc/0976-4879; https://doaj.org/toc/0975-7406 |
| DOI: | 10.4103/jpbs.jpbs_585_23 |
| URL الوصول: | https://doaj.org/article/c7c9eb5f274e46d08381d9b8eafe6310 |
| رقم الأكسشن: | edsdoj.7c9eb5f274e46d08381d9b8eafe6310 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09764879 09757406 |
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| DOI: | 10.4103/jpbs.jpbs_585_23 |