دورية أكاديمية
Lower gastrointestinal bleeding in a patient receiving sevelamer: Case report
| العنوان: | Lower gastrointestinal bleeding in a patient receiving sevelamer: Case report |
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| المؤلفون: | Tessa S Schoot, Tessa EH Römkens, Ellen K Hoogeveen |
| المصدر: | SAGE Open Medical Case Reports, Vol 9 (2021) |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Phosphate binders such as sevelamer are widely used in patients with chronic kidney disease to lower serum phosphate levels. We present a case of a 67-year-old woman with lower gastrointestinal bleeding after 9 days of using sevelamer carbonate (Renvela ® ). Sigmoidoscopy revealed multiple deep ulcers (diameter 10–15 mm) and mucosal oedema. Histologic examination showed deposition of sevelamer crystals in these rectal ulcers. We hypothesized that the lower gastrointestinal bleeding was caused by deposition of sevelamer crystals. After cessation of sevelamer, gastrointestinal bleeding stopped. Deposition of sevelamer crystals in the gastrointestinal tract is a rare complication of sevelamer therapy. There are only 17 other recorded cases of gastrointestinal deposition of sevelamer crystals. This adverse effect should be considered in all patients taking sevelamer who present with gastrointestinal symptoms, such as gastrointestinal bleeding and abdominal pain. When sevelamer is discontinued, symptoms and mucosal damage appear to revert. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-313X 2050313X |
| Relation: | https://doaj.org/toc/2050-313X |
| DOI: | 10.1177/2050313X211000488 |
| URL الوصول: | https://doaj.org/article/7ca8e121fcb8485ca692fdd34a0b7b33 |
| رقم الأكسشن: | edsdoj.7ca8e121fcb8485ca692fdd34a0b7b33 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050313X |
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| DOI: | 10.1177/2050313X211000488 |