دورية أكاديمية
优格列汀单药治疗2型糖尿病:一项12周随机、双盲、安慰剂对照的II期研究
| العنوان: | 优格列汀单药治疗2型糖尿病:一项12周随机、双盲、安慰剂对照的II期研究 |
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| المؤلفون: | Xin Wang, Ying Wang, Xiaolan Yong, Bojun Wu, Zilin Sun, Ning Lou, Qing Wen, Yufang Zhang, Shiyun Li, Jiarui Li, Yan He, Jinluo Cheng, Xiangdong Zhong, Jing Shen, Wenying Yang |
| المصدر: | Journal of Diabetes, Vol 14, Iss 12, Pp 822-830 (2022) |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | 优格列汀, 单药疗法, 2型糖尿病, DPP‐4抑制剂, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Abstract Background The new xanthine dipeptidyl peptidase‐4 inhibitor yogliptin has exhibited excellent hypoglycemic activity in experimental disease models. The present work aimed to assess the efficacy of yogliptin as a monotherapy in individuals with type 2 diabetes mellitus (T2DM). Methods A 12‐week, double‐blind, placebo‐controlled phase II study was performed. T2DM patients (new diagnosis or inadequately controlled) were randomly divided into groups (1:1:1:1) and administered either a placebo or weekly doses of 200, 300, or 400 mg yogliptin, respectively. The primary efficacy end point in this analysis was hemoglobin A1c (HbA1c) change at 12 weeks relative to baseline. Relevant secondary outcomes were also examined, including fasting plasma glucose (FPG), 2 h‐postprandial plasma glucose (PPG), body weight, and the rate of individuals who achieved the treatment goal of HbA1c ≤ 7% at 12 weeks from baseline. Results A total of 81 cases who received either the placebo (20 cases) or 200 (20 cases), 300 (20 cases), or 400 (21 cases) mg yogliptin were examined in the full analysis set. At 12 weeks, changes in HbA1c levels from baseline were 0.17 (−0.22, 0.57) in the placebo group, and −0.75 (−1.15, −0.35), −0.52 (−0.93, −0.11) and −1.02 (−1.41, −0.64) (mean % [95% confidence interval], p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1753-0407 1753-0393 |
| Relation: | https://doaj.org/toc/1753-0393; https://doaj.org/toc/1753-0407 |
| DOI: | 10.1111/1753-0407.13337 |
| URL الوصول: | https://doaj.org/article/7cc74c7dbeac4893b9af0ab13fe17629 |
| رقم الأكسشن: | edsdoj.7cc74c7dbeac4893b9af0ab13fe17629 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17530407 17530393 |
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| DOI: | 10.1111/1753-0407.13337 |