دورية أكاديمية
Additional blood meals increase sporozoite infection in Anopheles mosquitoes but not Plasmodium falciparum genetic diversity
| العنوان: | Additional blood meals increase sporozoite infection in Anopheles mosquitoes but not Plasmodium falciparum genetic diversity |
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| المؤلفون: | Lorenz M. Hofer, Prisca A. Kweyamba, Rajabu M. Sayi, Mohamed S. Chabo, Rehema Mwanga, Sonali L. Maitra, Mariam M. Somboka, Annina Schnoz, Monica Golumbeanu, Pierre H. H. Schneeberger, Amanda Ross, Tibebu Habtewold, Christian Nsanzabana, Sarah J. Moore, Mgeni M. Tambwe |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Malaria, Plasmodium falciparum, Anopheles gambiae, Parasite development, Oocysts, Sporozoites, Medicine, Science |
| الوصف: | Abstract The availability of nutrients from mosquito blood meals accelerates the development of Plasmodium falciparum laboratory strains in artificially infected Anopheles gambiae mosquitoes. The impact of multiple blood meals on the number of P. falciparum genotypes developing from polyclonal natural human malaria infections (field-isolates) remains unexplored. Here, we experimentally infect An. gambiae with P. falciparum field-isolates and measure the impact of an additional non-infectious blood meal on parasite development. We also assess parasite genetic diversity at the blood stage level of the parasite in the human host and of the sporozoites in the mosquito. Additional blood meals increase the sporozoite infection prevalence and intensity, but do not substantially affect the genetic diversity of sporozoites in the mosquito. The most abundant parasite genotypes in the human blood were transmitted to mosquitoes, suggesting that there was no preferential selection of specific genotypes. This study underlines the importance of additional mosquito blood meals for the development of parasite field-isolates in the mosquito host. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-67990-y |
| URL الوصول: | https://doaj.org/article/7cfcc3a92bad41b68ec90dbbb6d0b677 |
| رقم الأكسشن: | edsdoj.7cfcc3a92bad41b68ec90dbbb6d0b677 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-67990-y |