دورية أكاديمية
أعرض في EDS

Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy

التفاصيل البيبلوغرافية
العنوان: Low Systemic Inflammation Response Index Predicts Good Prognosis in Locally Advanced Pancreatic Carcinoma Patients Treated with Concurrent Chemoradiotherapy
المؤلفون: Erkan Topkan, Huseyin Mertsoylu, Ahmet Kucuk, Ali Ayberk Besen, Ahmet Sezer, Duygu Sezen, Yasemin Bolukbasi, Ugur Selek, Berrin Pehlivan
المصدر: Gastroenterology Research and Practice, Vol 2020 (2020)
بيانات النشر: Wiley, 2020.
سنة النشر: 2020
المجموعة: LCC:Diseases of the digestive system. Gastroenterology
مصطلحات موضوعية: Diseases of the digestive system. Gastroenterology, RC799-869
الوصف: Background. We investigated the prognostic significance of pretreatment systemic inflammation response index (SIRI) in locally advanced pancreatic carcinoma (LAPC) patients treated with concurrent chemoradiotherapy (CRT). Methods. Present retrospective cohort analysis investigated consecutive 154 LAPC patients who received radical CRT. The SIRI was defined as: SIRI=neutrophil×monocyte/lymphocyte counts. Ideal SIRI cutoff(s) influencing overall survival (OS) and progression-free survival (PFS) results were sought by using receiver operating characteristic (ROC) curve analysis. The primary endpoint was the interaction between the SIRI and OS results. Results. The median follow-up, PFS, and OS durations were 14.3 (range: 2.9-74.6), 7.9 [%95 confidence interval (CI): 5.7-10.1), and 14.7 months (%95 CI: 11.4-18.0) for the entire cohort, respectively. ROC curve analyses determined the ideal SIRI cutoff that exhibiting a significant link with OS and PFS outcomes at the rounded 1.6 point (AUC: 74.3%; sensitivity: 73.8%; specificity: 70.1%).The SIRI 90 U/mL) appeared as the other significant associates of better OS and PFS in univariate analyses, yet the results of multivariate analyses confirmed the SIRI
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-6121
1687-630X
Relation: https://doaj.org/toc/1687-6121; https://doaj.org/toc/1687-630X
DOI: 10.1155/2020/5701949
URL الوصول: https://doaj.org/article/c7d2c5f78af04999aaeaa487e023879a
رقم الأكسشن: edsdoj.7d2c5f78af04999aaeaa487e023879a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16876121
1687630X
DOI:10.1155/2020/5701949