دورية أكاديمية
The predictive value of PFKFB3 in bladder cancer prognosis
| العنوان: | The predictive value of PFKFB3 in bladder cancer prognosis |
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| المؤلفون: | Dongxu Qiu, Bin Zhao, Wenda Wang, Guoyang Zheng, Zhan Wang, Xu Wang, Yanan Li, Zhangcheng Liao, Yang Zhao, Yushi Zhang |
| المصدر: | Heliyon, Vol 10, Iss 10, Pp e31347- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Bladder cancer, Overall survival, 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, PFKFB3, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-3 (PFKFB3) influences cancer progression via participating in tumor aerobic glycolysis. In this study, we aimed to evaluate the prognostic significance of PFKFB3 in bladder cancer (BLCA) patients by analyzing a combination of publicly available databases, clinical patient data, and bladder tumor samples from our hospital. Single-cell and bulk RNA-seq data of bladder cancer, obtained from ENA, GEO, and TCGA databases, were utilized for our analysis. The results indicated that PFKFB3 mRNA expression was markedly elevated in bladder cancer compared to paired normal tissue. Furthermore, BLCA patients with high PFKFB3 expression exhibited a significantly worse prognosis (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240584402407378X; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e31347 |
| URL الوصول: | https://doaj.org/article/7d313368989b49bb856dbd1e231c1420 |
| رقم الأكسشن: | edsdoj.7d313368989b49bb856dbd1e231c1420 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e31347 |