دورية أكاديمية
Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it’s role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review
العنوان: | Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it’s role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review |
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المؤلفون: | A. Ullah, N. Ali, S. Ahmad, S. U. Rahman, S. Alghamdi, A. M. Bannunah, R. Ali, A. Aman, J. Khan, H. Hussain, M. U. K. Sahibzada |
المصدر: | Brazilian Journal of Biology, Vol 83 (2021) |
بيانات النشر: | Instituto Internacional de Ecologia, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Science LCC:Biology (General) LCC:Zoology LCC:Botany |
مصطلحات موضوعية: | Diabetes mellitus, Glycogen Synthase Kinase-3 (GSK-3), Glucose homeostasis, Fluoroquinolones, Science, Biology (General), QH301-705.5, Zoology, QL1-991, Botany, QK1-989 |
الوصف: | Abstract Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world. This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. The GSK-3, that is the key enzyme is normally showing its actions by various mechanisms that include its phosphorylation, formation of protein complexes, and other cellular distribution and thus it control and directly affects cellular morphology, its growth, mobility and apoptosis of the cell. Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer’s disease and cancer. Fluoroquinolones are the most common class of drugs that shows dysglycemic effects via interacting with GSK-3 enzyme. Therefore, it is the need of the day to properly understand functions and mechanisms of GSK-3, especially its role in glucose homeostasis via effects on glycogen synthase. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1678-4375 1519-6984 |
Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842023000100236&tlng=en; https://doaj.org/toc/1678-4375 |
DOI: | 10.1590/1519-6984.250179 |
URL الوصول: | https://doaj.org/article/7d6107adfed5472c8ee19c810d41fe84 |
رقم الأكسشن: | edsdoj.7d6107adfed5472c8ee19c810d41fe84 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 16784375 15196984 |
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DOI: | 10.1590/1519-6984.250179 |