دورية أكاديمية
Amniotic Membrane Transplantation for Persistent Epithelial Defects and Ulceration due to Pseudomonas Keratitis in a Rabbit Model
| العنوان: | Amniotic Membrane Transplantation for Persistent Epithelial Defects and Ulceration due to Pseudomonas Keratitis in a Rabbit Model |
|---|---|
| المؤلفون: | Mohammad Mehdi Soltan Dallal, Farhad Nikkhahi, Seyed Mostafa Imeni, Saber Molaei, Seyed Kazem Hosseini, Zohreh Kalafi, Sara Sharifi Yazdi, Hedroosha Molla Agha Mirzaei |
| المصدر: | Journal of Ophthalmic & Vision Research, Vol 16, Iss 4, Pp 552-557 (2021) |
| بيانات النشر: | Knowledge E, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | ciprofloxacin, human amniotic membrane, keratitis, pseudomonas aeruginosa, rabbit, Ophthalmology, RE1-994 |
| الوصف: | Abstract Purpose: The use of amniotic membrane has been suggested in the treatment of infectious keratitis for its intrinsic anti-infective properties probably mediated by its anti-inflammatory effects. The aim of this study was to investigate the effect of amniotic membrane transplantation (AMT) along with ciprofloxacin to cure the primary stages of Pseudomonas keratitis. Methods: In total, 28 rabbits were selected and divided in four groups as follows: group 1 as control, group 2 with amniotic membrane, group 3 with ciprofloxacin, and group 4 with amniotic membrane combined with ciprofloxacin. About 0.05 cc suspension of Pseudomonas aeruginosa, 27853 ATCC was injected into corneal stroma. Results: The results showed groups of AMT, AMT + ciprofloxacin, and ciprofloxacin had 0% perforation while the control group had 85.6%. Average infiltration of 5.5 mm was observed in ciprofloxacin group, 5 mm in AMT + ciprofloxacin group, 24 mm in AMT group, and finally 23.75 mm for control. Amniotic membrane showed to be effective in prevention of cornea perforation as well as remission of Pseudomonas keratitis. There was no significant difference between ciprofloxacin groups in comparison with ciprofloxacin + AMT group. However, regarding the anti-inflammatory effect, the process of improvement of inflammation in ciprofloxacin + AMT group was faster. Conclusion: Transplantation of amniotic membrane in the primary stages of Pseudomonas keratitis treatment remarkably prevents the disease and it can be used to control its process. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-2010 2008-322X |
| Relation: | https://doaj.org/toc/2008-2010; https://doaj.org/toc/2008-322X |
| DOI: | 10.18502/jovr.v16i4.9744 |
| URL الوصول: | https://doaj.org/article/7d7f2d91b1fd43bd86a451037a71b539 |
| رقم الأكسشن: | edsdoj.7d7f2d91b1fd43bd86a451037a71b539 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20082010 2008322X |
|---|---|
| DOI: | 10.18502/jovr.v16i4.9744 |