دورية أكاديمية
GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis
| العنوان: | GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis |
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| المؤلفون: | Chunxiao Mou, Hui Meng, Kaichuang Shi, Yanmei Huang, Meiqi Liu, Zhenhai Chen |
| المصدر: | Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-20 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Cytology |
| مصطلحات موضوعية: | Getah virus, nsP2 protein, Interferon, Nuclear localization, Viral pathogensis, Medicine, Cytology, QH573-671 |
| الوصف: | Abstract Getah virus (GETV) was becoming more serious and posing a potential threat to animal safety and public health. Currently, there is limited comprehension regarding the pathogenesis and immune evasion mechanisms employed by GETV. Our study reveals that GETV infection exhibits the capacity for interferon antagonism. Specifically, the nonstructural protein nsP2 of GETV plays a crucial role in evading the host immune response. GETV nsP2 effectively inhibits the induction of IFN-β by blocking the phosphorylation and nuclear translocation of IRF3. Additionally, GETV nsP2 hinders the phosphorylation of STAT1 and its nuclear accumulation, leading to significantly impaired JAK-STAT signaling. Furthermore, the amino acids K648 and R649, situated in the C-terminal region of GETV nsP2, play a crucial role in facilitating nuclear localization. Not only do they affect the interference of nsP2 with the innate immune response, but they also exert an influence on the pathogenicity of GETV in mice. In summary, our study reveals novel mechanisms by which GETV evades the immune system, thereby offering a foundation for comprehending the pathogenic nature of GETV. Video Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-023-01392-x |
| URL الوصول: | https://doaj.org/article/7e094e176c014855b127e1357a642adb |
| رقم الأكسشن: | edsdoj.7e094e176c014855b127e1357a642adb |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1478811X |
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| DOI: | 10.1186/s12964-023-01392-x |