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24-Month Outcomes of Primary Care Web-Based Depression Prevention Intervention in Adolescents: Randomized Clinical Trial

التفاصيل البيبلوغرافية
العنوان: 24-Month Outcomes of Primary Care Web-Based Depression Prevention Intervention in Adolescents: Randomized Clinical Trial
المؤلفون: Van Voorhees, Benjamin, Gladstone, Tracy R G, Sobowale, Kunmi, Brown, C Hendricks, Aaby, David A, Terrizzi, Daniela A, Canel, Jason, Ching, Eumene, Berry, Anita D, Cantorna, James, Eder, Milton, Beardslee, William, Fitzgibbon, Marian, Marko-Holguin, Monika, Schiffer, Linda, Lee, Miae, de Forest, Sarah A, Sykes, Emily E, Suor, Jennifer H, Crawford, Theodore J, Burkhouse, Katie L, Goodwin, Brady C, Bell, Carl
المصدر: Journal of Medical Internet Research, Vol 22, Iss 10, p e16802 (2020)
بيانات النشر: JMIR Publications, 2020.
سنة النشر: 2020
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Public aspects of medicine
مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
الوصف: BackgroundAdolescent depression carries a high burden of disease worldwide, but access to care for this population is limited. Prevention is one solution to curtail the negative consequences of adolescent depression. Internet interventions to prevent adolescent depression can overcome barriers to access, but few studies examine long-term outcomes. ObjectiveThis study compares CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training), an internet-based intervention, to a general health education active control for depression onset at 12 and 24 months in adolescents presenting to primary care settings. MethodsA 2-site randomized trial, blinded to the principal investigators and assessors, was conducted comparing Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training to health education to prevent depressive episodes in 369 adolescents (193 youths were randomly assigned to Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training and 176 to health education) with subthreshold depressive symptoms or prior depressive episodes. Participants were recruited from primary care settings in the United States. The primary outcome was the occurrence of a depressive episode, determined by the Depression Symptom Rating. The secondary outcome was functioning, measured by the Global Assessment Scale. ResultsIn intention-to-treat analyses, the adjusted hazard ratio favoring Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training for first depressive episode was not statistically significant at 12 months (hazard ratio 0.77, 95% CI 0.42-1.40, P=.39) and 24 months (hazard ratio 0.87, 95% CI 0.52-1.47, P=.61). Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training provided preventive benefit for first depressive episode for those with mild hopelessness or at least moderate paternal monitoring at baseline. Global Assessment Scale scores improved comparably in both groups (intention-to-treat). ConclusionsA technology-based intervention for adolescent depression prevention implemented in primary care did not have additional benefit at 12 or 24 months. Further research is necessary to determine whether internet interventions have long-term benefit. Trial RegistrationClinicalTrials.gov NCT01893749; http://clinicaltrials.gov/ct2/show/NCT01893749.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1438-8871
Relation: https://www.jmir.org/2020/10/e16802; https://doaj.org/toc/1438-8871
DOI: 10.2196/16802
URL الوصول: https://doaj.org/article/e7e4bfa368904ccaa414884c0d4390b9
رقم الأكسشن: edsdoj.7e4bfa368904ccaa414884c0d4390b9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14388871
DOI:10.2196/16802