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Pathological Functions of Lysosomal Ion Channels in the Central Nervous System

التفاصيل البيبلوغرافية
العنوان: Pathological Functions of Lysosomal Ion Channels in the Central Nervous System
المؤلفون: Jianke Cen, Nan Hu, Jiawen Shen, Yongjing Gao, Huanjun Lu
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6565 (2024)
بيانات النشر: MDPI AG, 2024.
سنة النشر: 2024
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: lysosomes, ion channel, central nervous system, immune inflammation, disease, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl−, Na+, H+, and K+ across lysosomal membranes in response to osmotic stimulus, nutrient-dependent signals, and cellular stresses. These ion channels serve as the crucial transducers of cell signals and are essential for the regulation of lysosomal biogenesis, motility, membrane contact site formation, and lysosomal homeostasis. In terms of pathophysiology, genetic variations in these channel genes have been associated with the development of lysosomal storage diseases, neurodegenerative diseases, inflammation, and cancer. This review aims to discuss the current understanding of the role of these ion channels in the central nervous system and to assess their potential as drug targets.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/25/12/6565; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms25126565
URL الوصول: https://doaj.org/article/d7e82228be184e32a375ce70f7d04c0c
رقم الأكسشن: edsdoj.7e82228be184e32a375ce70f7d04c0c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms25126565