دورية أكاديمية
Pathological Functions of Lysosomal Ion Channels in the Central Nervous System
العنوان: | Pathological Functions of Lysosomal Ion Channels in the Central Nervous System |
---|---|
المؤلفون: | Jianke Cen, Nan Hu, Jiawen Shen, Yongjing Gao, Huanjun Lu |
المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 12, p 6565 (2024) |
بيانات النشر: | MDPI AG, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | lysosomes, ion channel, central nervous system, immune inflammation, disease, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl−, Na+, H+, and K+ across lysosomal membranes in response to osmotic stimulus, nutrient-dependent signals, and cellular stresses. These ion channels serve as the crucial transducers of cell signals and are essential for the regulation of lysosomal biogenesis, motility, membrane contact site formation, and lysosomal homeostasis. In terms of pathophysiology, genetic variations in these channel genes have been associated with the development of lysosomal storage diseases, neurodegenerative diseases, inflammation, and cancer. This review aims to discuss the current understanding of the role of these ion channels in the central nervous system and to assess their potential as drug targets. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/25/12/6565; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms25126565 |
URL الوصول: | https://doaj.org/article/d7e82228be184e32a375ce70f7d04c0c |
رقم الأكسشن: | edsdoj.7e82228be184e32a375ce70f7d04c0c |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
---|---|
DOI: | 10.3390/ijms25126565 |