A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation

التفاصيل البيبلوغرافية
العنوان:	A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation
المؤلفون:	Jianfeng Wu, Kang Yang, Shaowei Cai, Xiaohan Zhang, Lichen Hu, Fanjia Lin, Su-qin Wu, Changchun Xiao, Wen-Hsien Liu, Jiahuai Han
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Plasma cells are terminally differentiated B cells that are specialized for antibody secretion. Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional regulatory program by BLIMP1.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-34969-0
URL الوصول:	https://doaj.org/article/7eacb188fa0445489b0d57415f695ccf
رقم الأكسشن:	edsdoj.7eacb188fa0445489b0d57415f695ccf
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-34969-0