دورية أكاديمية
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time
| العنوان: | Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time |
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| المؤلفون: | Ilse Vanhorebeek, Grégoire Coppens, Fabian Güiza, Inge Derese, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Greet Van den Berghe |
| المصدر: | Clinical Epigenetics, Vol 15, Iss 1, Pp 1-18 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Critical illness, Paediatrics, Children, Steroidogenesis, Sex steroids, Aldosterone, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract Background Former critically ill children show an epigenetic age deceleration 2 years after paediatric intensive care unit (PICU) admission as compared with normally developing healthy children, with stunted growth in height 2 years further in time as physical correlate. This was particularly pronounced in children who were 6 years or older at the time of critical illness. As this age roughly corresponds to the onset of adrenarche and further pubertal development, a relation with altered activation of endocrine pathways is plausible. We hypothesised that children who have been admitted to the PICU, sex- and age-dependently show long-term abnormal DNA methylation within genes involved in steroid hormone synthesis or steroid sulphation/desulphation, possibly aggravated by in-PICU glucocorticoid treatment, which may contribute to stunted growth in height further in time after critical illness. Results In this preplanned secondary analysis of the multicentre PEPaNIC-RCT and its follow-up, we compared the methylation status of genes involved in the biosynthesis of steroid hormones (aldosterone, cortisol and sex hormones) and steroid sulphation/desulphation in buccal mucosa DNA (Infinium HumanMethylation EPIC BeadChip) from former PICU patients at 2-year follow-up (n = 818) and healthy children with comparable sex and age (n = 392). Adjusting for technical variation and baseline risk factors and corrected for multiple testing (false discovery rate |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1868-7083 |
| Relation: | https://doaj.org/toc/1868-7083 |
| DOI: | 10.1186/s13148-023-01530-9 |
| URL الوصول: | https://doaj.org/article/7eb3917e2c2d4eaaafcebd047e67adc3 |
| رقم الأكسشن: | edsdoj.7eb3917e2c2d4eaaafcebd047e67adc3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 18687083 |
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| DOI: | 10.1186/s13148-023-01530-9 |