دورية أكاديمية
Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming.
| العنوان: | Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming. |
|---|---|
| المؤلفون: | Josh Jones, Qiaojuan Shi, Rahul R Nath, Ilana L Brito |
| المصدر: | PLoS ONE, Vol 19, Iss 2, p e0297897 (2024) |
| بيانات النشر: | Public Library of Science (PLoS), 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Fusobacterium nucleatum (Fn) and enterotoxigenic Bacteroides fragilis (ETBF) are two pathobionts consistently enriched in the gut microbiomes of patients with colorectal cancer (CRC) compared to healthy counterparts and frequently observed for their direct association within tumors. Although several molecular mechanisms have been identified that directly link these organisms to features of CRC in specific cell types, their specific effects on the epithelium and local immune compartment are not well-understood. To fill this gap, we leveraged single-cell RNA sequencing (scRNA-seq) on wildtype mice and mouse model of CRC. We find that Fn and ETBF exacerbate cancer-like transcriptional phenotypes in transit-amplifying and mature enterocytes in a mouse model of CRC. We also observed increased T cells in the pathobiont-exposed mice, but these pathobiont-specific differences observed in wildtype mice were abrogated in the mouse model of CRC. Although there are similarities in the responses provoked by each organism, we find pathobiont-specific effects in Myc-signaling and fatty acid metabolism. These findings support a role for Fn and ETBF in potentiating tumorigenesis via the induction of a cancer stem cell-like transit-amplifying and enterocyte population and the disruption of CTL cytotoxic function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297897&type=printable; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0297897&type=printable |
| DOI: | 10.1371/journal.pone.0297897 |
| URL الوصول: | https://doaj.org/article/7f03280924d84d9ab20a07cc24b1b89d |
| رقم الأكسشن: | edsdoj.7f03280924d84d9ab20a07cc24b1b89d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0297897&type=printable |