دورية أكاديمية
Serum Levels of Classical HLA Class I Antigen in HIV-Infected patients during antiretroviral therapy. Correlation with the clinical outcome
| العنوان: | Serum Levels of Classical HLA Class I Antigen in HIV-Infected patients during antiretroviral therapy. Correlation with the clinical outcome |
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| المؤلفون: | G. Murdaca, P. Cagnati, F. Puppo |
| المصدر: | Journal of Biological Research, Vol 82, Iss 1 (2009) |
| بيانات النشر: | PAGEPress Publications, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Soluble HLA Molecules, HIV, AIDS, HAART, Biology (General), QH301-705.5 |
| الوصف: | Aim. Human major histocompatibility complex class I antigens (HLA-A, -B, and -C) are heterodimetric molecules composed of a heavy chain non covalently associated with an invariant protein known as B2-microglobulin. Besides being expressed on the membrane of the large majority of nucleated cells, HLA class I antigens are found in serum (sHLA-I). We have previously detected a significant increase in the serum level of B2-microglobulin-associated HLA-I antigens in HIV-infected patients as compared to HIV-negative controls. Materials and methods. The introduction of the Highly Active Antiretroviral Theraphy (HAART) has modified the clinical course of the disease and decreased the AIDS-related morbidity and mortality. Therefore, we measured the levels of sHLA-I antigens in 64 HIV-infected patients before and during HAART treatment and correlated them with the imunological and virological response to the antiretroviral treatment. Result and conclusions. Serum sHLA-I antigen level was elevaed in all HIV-infected subjects before and significantly decreased after 36 months of HAART treatment correlated with the decrease of plasma HIV-RNA level and with the increased od CD4+ T-lymphocyte number. These results suggest that the measurement of sHLA-I antigens serum level might represent a useful surrogate marker to monitor HIV-positive subjects undergoing HAART treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1826-8838 2284-0230 |
| Relation: | http://www.pagepressjournals.org/index.php/jbr/article/view/4793; https://doaj.org/toc/1826-8838; https://doaj.org/toc/2284-0230 |
| DOI: | 10.4081/jbr.2009.4793 |
| URL الوصول: | https://doaj.org/article/7f21034e93654058840e692a405b9a72 |
| رقم الأكسشن: | edsdoj.7f21034e93654058840e692a405b9a72 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18268838 22840230 |
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| DOI: | 10.4081/jbr.2009.4793 |