دورية أكاديمية
p600 Plays Essential Roles in Fetal Development.
| العنوان: | p600 Plays Essential Roles in Fetal Development. |
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| المؤلفون: | Takeo Nakaya, Kei-Ichiro Ishiguro, Camille Belzil, Anna M Rietsch, Qunyan Yu, Shin-Ichi Mizuno, Roderick T Bronson, Yan Geng, Minh Dang Nguyen, Koichi Akashi, Piotr Sicinski, Yoshihiro Nakatani |
| المصدر: | PLoS ONE, Vol 8, Iss 6, p e66269 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | p600 is a multifunctional protein implicated in cytoskeletal organization, integrin-mediated survival signaling, calcium-calmodulin signaling and the N-end rule pathway of ubiquitin-proteasome-mediated proteolysis. While push, the Drosophila counterpart of p600, is dispensable for development up to adult stage, the role of p600 has not been studied during mouse development. Here we generated p600 knockout mice to investigate the in vivo functions of p600. Interestingly, we found that homozygous deletion of p600 results in lethality between embryonic days 11.5 and 13.5 with severe defects in both embryo and placenta. Since p600 is required for placental development, we performed conditional disruption of p600, which deletes selectively p600 in the embryo but not in the placenta. The conditional mutant embryos survive longer than knockout embryos but ultimately die before embryonic day 14.5. The mutant embryos display severe cardiac problems characterized by ventricular septal defects and thin ventricular walls. These anomalies are associated with reduced activation of FAK and decreased expression of MEF2, which is regulated by FAK and plays a crucial role in cardiac development. Moreover, we observed pleiotropic defects in the liver and brain. In sum, our study sheds light on the essential roles of p600 in fetal development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3688873?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0066269 |
| URL الوصول: | https://doaj.org/article/7f8a1bf5423148d7aed0c24bfa33a48c |
| رقم الأكسشن: | edsdoj.7f8a1bf5423148d7aed0c24bfa33a48c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0066269 |