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Longitudinal assessment of sweat-based TNF-alpha in inflammatory bowel disease using a wearable device

التفاصيل البيبلوغرافية
العنوان: Longitudinal assessment of sweat-based TNF-alpha in inflammatory bowel disease using a wearable device
المؤلفون: Robert P. Hirten, Kai-Chun Lin, Jessica Whang, Sarah Shahub, Drew Helmus, Sriram Muthukumar, Bruce E. Sands, Shalini Prasad
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Wearable devices can non-invasively monitor patients with chronic diseases. Sweat is an easily accessible biofluid for continuous sampling of analytes, including inflammatory markers and cytokines. We evaluated a sweat sensing wearable device in subjects with and without inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract. Participants with an IBD related hospital admission and a C-reactive protein level above 5 mg/L wore a sweat sensing wearable device for up to 5 days. Tumor necrosis factor-alpha (TNF-α) levels were continually assessed in the sweat via the sensor, and daily in the blood. A second cohort of healthy subjects without chronic diseases wore the device for up to 48 h. Twenty-eight subjects were enrolled. In the 16 subjects with IBD, a moderate linear relationship between serum and sweat TNF-α levels was observed (R2 = 0.72). Subjects with IBD were found to have a mean sweat TNF-α level of 2.11 pg/mL, compared to a mean value of 0.19 pg/mL in 12 healthy controls (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-53522-1
URL الوصول: https://doaj.org/article/ddc7fc6b4f9642f6b6eacdc439d3c200
رقم الأكسشن: edsdoj.7fc6b4f9642f6b6eacdc439d3c200
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-53522-1