دورية أكاديمية
Gene Expression and Clinical Characteristics of Molecular Targeted Therapy in Non-small Cell Lung Cancer Patients in Shandong
| العنوان: | Gene Expression and Clinical Characteristics of Molecular Targeted Therapy in Non-small Cell Lung Cancer Patients in Shandong |
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| المؤلفون: | Xiuli QIAO, Dan AI, Honglu LIANG, Dianbin MU, Qisen GUO |
| المصدر: | Chinese Journal of Lung Cancer, Vol 20, Iss 1, Pp 14-20 (2017) |
| بيانات النشر: | Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Lung neoplasms, Molecular target therapy, Epidermal growth factor receptor, Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase, ROS proto-oncogene 1, Kirsten rat sarcoma viral oncogene, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background and objective Molecular targeted therapy has gradually become an important treatment for lung cancer, the aim of this research is to analyze the clinicopathologic features associated with the gene mutation status of epidermal growth factor receptor (EGFR), echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) and Kirsten rat sarcoma viral oncogene (KRAS) in non-small cell lung cancer (NSCLC) patients and determine the most likely populations to benefit from molecular target therapy treatment. Methods The mutation status of EGFR, EML4-ALK fusion gene, ROS1 and KARS gene were determined by Real-time PCR, the relationship between clinical pathologic features and concomitant gene were analyzed with χ2 test by SPSS software 19.0. Results A total of 514 specimens from Shandong tumor hospital were collected from NSCLC patients between January 2014 and May 2016. The total mutation rate of EGFR gene was 36.70%, major occurred in exon 19 (36.61%) and exon 21 (51.36%), respectively, and EGFR mutations usually occurred in female, non-smoking and adenocarcinoma patients (P0.05). ROS1 fusion gene was detected in 136 cases, the positive rate was 3.67%, all patients were 60 years old, and the difference was statistically significant (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1009-3419 1999-6187 |
| Relation: | https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2017.01.02 |
| URL الوصول: | https://doaj.org/article/7ff4ed5608024d32b1d8e0c64946b325 |
| رقم الأكسشن: | edsdoj.7ff4ed5608024d32b1d8e0c64946b325 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10093419 19996187 |
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| DOI: | 10.3779/j.issn.1009-3419.2017.01.02 |