دورية أكاديمية
أعرض في EDS

The Relationship between HLA-G Gene Polymorphisms and Repeated Implantation Failure in Infertile Couples Undergoing Assisted Reproductive Technique

التفاصيل البيبلوغرافية
العنوان: The Relationship between HLA-G Gene Polymorphisms and Repeated Implantation Failure in Infertile Couples Undergoing Assisted Reproductive Technique
المؤلفون: Zahra Kuroshli, Hamid Gourabi, Masood Bazrgar, Mohammad Hossein Sanati, Masoud Zamani Esteki
المصدر: Iranian Journal of Allergy, Asthma and Immunology, Vol 14, Iss 5 (2015)
بيانات النشر: Tehran University of Medical Sciences, 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
مصطلحات موضوعية: ART, HLA-G polymorphism, Implantation, RIF, Medicine
الوصف: HLA-G is a tolerogenic molecule that expresses in cytotrophoblast cells and plays an important role in immune response suppression in maternal decidua. Interactions between the extracellular domains of the HLA-G protein with cell receptors of the immune system are well-known.This study investigated the association between HLA-G gene polymorphism with repeated implantation failure (RIF). We used PCR followed by the sequencing technique for exons 2, 3, and 4, as well as intron 2 of the HLA-G gene in 100 couples with histories of two or more failed assisted reproductive technique (ART) attempts. The data were compared with the results of our previous study.The results indicated that some alleles of the HLA-G gene such as: 0106, 010106, 01010106 and 0105N (null) alleles were significantly higher in the patient group compared to the control group (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1735-1502
1735-5249
Relation: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/602; https://doaj.org/toc/1735-1502; https://doaj.org/toc/1735-5249
URL الوصول: https://doaj.org/article/7ffceb82cdb94a8f897905368c9ec463
رقم الأكسشن: edsdoj.7ffceb82cdb94a8f897905368c9ec463
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17351502
17355249