دورية أكاديمية
Early Markers of Sickle Nephropathy in Children With Sickle Cell Anemia Are Associated With Red Cell Cation Transport Activity
| العنوان: | Early Markers of Sickle Nephropathy in Children With Sickle Cell Anemia Are Associated With Red Cell Cation Transport Activity |
|---|---|
| المؤلفون: | John Brewin, Sanjay Tewari, Anke Hannemann, Halima Al Balushi, Claire Sharpe, John S. Gibson, David C. Rees |
| المصدر: | HemaSphere, Vol 1, Iss 1 (2017) |
| بيانات النشر: | Wiley, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Abstract. The early stages of sickle cell nephropathy (SCN) manifest in children with sickle cell anemia (SCA) as hyperfiltration and proteinuria. The physiological conditions of the renovascular system are among the most conducive to hemoglobin S polymerization in the body and will magnify small changes in red cell volume thus crucially modulating intracellular concentrations of hemoglobin S. This large cross-sectional study of children with sickle cell anemia measured glomerular filtration rates and microalbuminuria to report prevalence, clinical correlates and uniquely, association with key red cell cation transport mechanisms. One hundred and twelve patients (mean age 10.7 ± 4.1) were recruited. The prevalence of hyperfiltration and microalbuminuria was 98% and 15.1%, respectively. Glomerular filtration rates did not vary with age, but proteinuria became more prevalent with increasing age. Both features associated with markers of hemolysis, while elevated hemoglobin F was protective, but no association was seen with systolic or diastolic blood pressure. In multivariate analysis, both Gardos channel (β = 0.476, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2572-9241 00000000 |
| Relation: | http://journals.lww.com/10.1097/HS9.0000000000000002; https://doaj.org/toc/2572-9241 |
| DOI: | 10.1097/HS9.0000000000000002 |
| URL الوصول: | https://doaj.org/article/80c56d0d1dd34c8780da8601f9514181 |
| رقم الأكسشن: | edsdoj.80c56d0d1dd34c8780da8601f9514181 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25729241 00000000 |
|---|---|
| DOI: | 10.1097/HS9.0000000000000002 |