دورية أكاديمية
Identifying the immune interactions underlying HLA class I disease associations
العنوان: | Identifying the immune interactions underlying HLA class I disease associations |
---|---|
المؤلفون: | Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith |
المصدر: | eLife, Vol 9 (2020) |
بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
مصطلحات موضوعية: | HLA, GWAS, CD8 T cell, natural killer cell, disease association, immunogenetics, Medicine, Science, Biology (General), QH301-705.5 |
الوصف: | Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of ‘protective’ or ‘detrimental’ CD8+ T cell responses which are restricted by the host HLA class I allotype. However, given the diverse receptors which are bound by HLA class I molecules, alternative interpretations are possible. As well as binding T cell receptors on CD8+ T cells, HLA class I molecules are important ligands for inhibitory and activating killer immunoglobulin-like receptors (KIRs) which are found on natural killer cells and some T cells; for the CD94:NKG2 family of receptors also expressed mainly by NK cells and for leukocyte immunoglobulin-like receptors (LILRs) on myeloid cells. The aim of this study is to develop an immunogenetic approach for identifying and quantifying the relative contribution of different receptor-ligand interactions to a given HLA class I disease association and then to use this approach to investigate the immune interactions underlying HLA class I disease associations in three viral infections: Human T cell Leukemia Virus type 1, Human Immunodeficiency Virus type 1 and Hepatitis C Virus as well as in the inflammatory condition Crohn’s disease. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2050-084X |
Relation: | https://elifesciences.org/articles/54558; https://doaj.org/toc/2050-084X |
DOI: | 10.7554/eLife.54558 |
URL الوصول: | https://doaj.org/article/80d1c97097094dba96ff172beca27a0b |
رقم الأكسشن: | edsdoj.80d1c97097094dba96ff172beca27a0b |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2050084X |
---|---|
DOI: | 10.7554/eLife.54558 |