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Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10.

التفاصيل البيبلوغرافية
العنوان: Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10.
المؤلفون: Jianhua Zhu, Ting Chen, Lin Yang, Zhoubin Li, Mei Mei Wong, Xiaoye Zheng, Xiaoping Pan, Li Zhang, Hui Yan
المصدر: PLoS ONE, Vol 7, Iss 11, p e46551 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: AIMS: Accumulating evidence suggest that numerous microRNAs (miRNAs) play important roles in cell proliferation, apoptosis, and differentiation, as well as various diseases that accompany inflammatory responses. Inflammation is known to be a major contributor to atherogenesis. Previous studies provide promising evidence in support of the role of miRNAs in cardiovascular disease. However, mechanistic data on these small molecules in atherosclerosis (AS) are still missing. The present study aims to investigate the potential role of miRNAs in AS. METHODS AND RESULTS: The miRNA transcriptase was verified by TaqMan real-time polymerase chain reaction assay. Thoracic aorta samples were obtained from Apolipoprotein E knockout mice, and plasma samples were from coronary artery disease (CAD) patients. The results showed that the miR-155 level was the most significantly elevated both in AS mice and CAD patients relative to the normal control. The functional role of miR-155 in the atherosclerotic path physiological process was also observed in vivo and in vitro. The observations suggested that miR-155 is a part of a negative feedback loop, which down-modulates inflammatory cytokine production and decreases AS progression. miR-155 was also found to mediate the inflammatory response and mitogen-activated protein kinase (MAPK) pathway by targeting mitogen-activated protein kinase kinase kinase 10. CONCLUSIONS: miR-155 contributes to the prevention of AS development and progression. It may also be involved in the posttranscriptional regulation of the inflammatory response and MAPK pathway by targeting mitogen-activated protein kinase kinase kinase 10.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3506618?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0046551
URL الوصول: https://doaj.org/article/80da64aa5e6b446987d126cac731d655
رقم الأكسشن: edsdoj.80da64aa5e6b446987d126cac731d655
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0046551