دورية أكاديمية
The Impact of Coronary Sinus Reducer on Arrhythmic Properties in Patients with Refractory Angina
| العنوان: | The Impact of Coronary Sinus Reducer on Arrhythmic Properties in Patients with Refractory Angina |
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| المؤلفون: | Miha Mrak, Tadej Žlahtič, Vito Starc, Maja Ivanovski, Matjaž Bunc, David Žižek |
| المصدر: | Reviews in Cardiovascular Medicine, Vol 24, Iss 12, p 368 (2023) |
| بيانات النشر: | IMR Press, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | electrocardiogram, refractory angina, arrhythmia, coronary sinus reducer, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background: Treatment with a coronary sinus reducer (CSR) is a new therapeutic option for refractory angina patients. Preclinical studies have shown antiarrhythmic properties of coronary sinus narrowing. The possible antiarrhythmic effect of CSR implantation is unknown. This study aimed to determine the possible antiarrhythmic effects of CSR implantation as assessed by high-resolution electrocardiogram (hrECG) parameters. Methods: 24 patients from the Crossroad study randomized to either CSR treatment (n = 12) or a sham procedure (n = 12) had hrECG recorded at baseline and after 6 months. T-peak and T-end interval (TpTe) defined as the time difference between the peak amplitude of the T wave and the global end of the T wave, spatial angle between QRS complex and T axis defined as the angle between the ventricular depolarization and repolarization vectors using maximal (QRSTP) and mean (QRSTM) vector amplitudes and spatial ventricular gradient (SVG) calculated as integral of ECG voltages over the entire QRST complex were analyzed. Additionally, we analyzed parameters of QT and heart rate variability using time and frequency domain. Results: At baseline, all analyzed parameters were comparable between both groups and heart rate remained constant. The intragroup analysis did not show any significant change in TpTe, QRSTP, QRSTM, SVG, QT, and heart rate variability at follow-up. Furthermore, intergroup comparison between CSR implantation and sham procedure also did not show any significant difference in the change of analyzed parameters. Conclusions: Compared to the sham procedure, CSR implantation did not demonstrate a significant impact on the arrhythmogenic substrate assessed with hrECG. Clinical Trial Registration: Unique Identifier: NCT04121845, https://classic.clinicaltrials.gov/ct2/show/NCT04121845. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1530-6550 25031236 |
| Relation: | https://www.imrpress.com/journal/RCM/24/12/10.31083/j.rcm2412368; https://doaj.org/toc/1530-6550 |
| DOI: | 10.31083/j.rcm2412368 |
| URL الوصول: | https://doaj.org/article/812b5705647a42598c25031236ca95cd |
| رقم الأكسشن: | edsdoj.812b5705647a42598c25031236ca95cd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15306550 25031236 |
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| DOI: | 10.31083/j.rcm2412368 |