دورية أكاديمية
Cardiovascular Involvement of a CD138-Negative Anaplastic Myeloma: A Diagnostic Dilemma
| العنوان: | Cardiovascular Involvement of a CD138-Negative Anaplastic Myeloma: A Diagnostic Dilemma |
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| المؤلفون: | Jui Choudhuri, Victor Janmey, Juan Ding, Denise Dailey, Yang Shi, Yanhua Wang |
| المصدر: | Hematology Reports, Vol 15, Iss 1, Pp 66-72 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | myeloma, anaplastic, plasmacytoid, cardiac, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Anaplastic myeloma (AM) is an extremely rare and aggressive histological variant of myeloma. It is characterized by extramedullary presentation in the young and has a poor prognosis. It can be a diagnostic challenge when myeloma is not suspected and even more when the immunophenotype is unexpected. We present a rare presentation of anaplastic myeloma with cardiovascular involvement. Though the patient did not have the typical clinical features of myeloma, except lytic lesion in the femur, the cardiac biopsy showed sheets of anaplastic cells, and some with multinucleation. There were also some areas with a more plasmacytoid appearance. The initial immunohistochemical panel was negative for CD3, CD20, CD138, AE1/3, and kappa. It was positive for lambda. This led to an extended panel which showed positivity for CD79a and MUM1 and negative for LMP-1, HHV-8, CD43, CD117, CD56, and CD30. Even the flow cytometry on the bone marrow showed a small population of atypical cells positive for CD38 and negative for CD138 with lambda restriction. This is an unusual case of anaplastic myeloma with cardiovascular involvement and CD138 negativity. This case highlights the need to add a panel of plasma cell markers when myeloma is suspected, and it is pertinent to read flow cytometry with caution to avoid missing atypical plasma cells which maybe CD38+/CD138−. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15010007 2038-8330 |
| Relation: | https://www.mdpi.com/2038-8330/15/1/7; https://doaj.org/toc/2038-8330 |
| DOI: | 10.3390/hematolrep15010007 |
| URL الوصول: | https://doaj.org/article/8146709169904bb3b90cda1d6fd2732d |
| رقم الأكسشن: | edsdoj.8146709169904bb3b90cda1d6fd2732d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15010007 20388330 |
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| DOI: | 10.3390/hematolrep15010007 |