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Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat

التفاصيل البيبلوغرافية
العنوان: Characterization of a novel model for atherosclerosis imaging: the apolipoprotein E-deficient rat
المؤلفون: Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx, Riemer H. J. A. Slart
المصدر: EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
بيانات النشر: SpringerOpen, 2023.
سنة النشر: 2023
المجموعة: LCC:Medical physics. Medical radiology. Nuclear medicine
مصطلحات موضوعية: Apolipoprotein E-deficient rat, Atherosclerosis, [18F]2-fluoro-2-deoxy-D-glucose, Positron emission tomography (PET), Medical physics. Medical radiology. Nuclear medicine, R895-920
الوصف: Abstract Background The apolipoprotein E-deficient (apoE −/− ) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. Recently, the apoE −/− rat has emerged as an alternative. With this study, we investigate the feasibility of using apoE −/− rats as an in vivo model for longitudinal atherosclerotic PET/CT imaging. Results ApoE −/− rats showed significantly higher [18F]FDG uptake than controls in the aortic arch (+ 18.5%, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2191-219X
Relation: https://doaj.org/toc/2191-219X
DOI: 10.1186/s13550-023-01055-5
URL الوصول: https://doaj.org/article/e815cbc78a3e4fae8f600fd68f64930c
رقم الأكسشن: edsdoj.815cbc78a3e4fae8f600fd68f64930c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2191219X
DOI:10.1186/s13550-023-01055-5