The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

التفاصيل البيبلوغرافية
العنوان:	The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
المؤلفون:	Jinjin Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann, Kun Zhang, Qingwu Liu, Ke Li, Weicang Wang, Hao Wang, Wei Xie, Qingwei Wang, Jiang Liu, Biao Zheng, Pei Zhang, Shixia Huang, Tieliu Shi, Biaohong Zhang, Yongyan Dang, Jiwu Chen, Bert W. O’Malley, Robb E. Moses, Ping Wang, Lei Li, Jianru Xiao, Alexander Hoffmann, Xiaotao Li
المصدر:	Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
بيانات النشر:	Nature Portfolio, 2016.
سنة النشر:	2016
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/ncomms10761
URL الوصول:	https://doaj.org/article/815ed3c7811843c397e9095adc1ff9cf
رقم الأكسشن:	edsdoj.815ed3c7811843c397e9095adc1ff9cf
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/ncomms10761