التفاصيل البيبلوغرافية
العنوان:
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
المؤلفون:
Jinjin Xu , Lei Zhou , Lei Ji , Fengyuan Chen , Karen Fortmann , Kun Zhang , Qingwu Liu , Ke Li , Weicang Wang , Hao Wang , Wei Xie , Qingwei Wang , Jiang Liu , Biao Zheng , Pei Zhang , Shixia Huang , Tieliu Shi , Biaohong Zhang , Yongyan Dang , Jiwu Chen , Bert W. O’Malley , Robb E. Moses , Ping Wang , Lei Li , Jianru Xiao , Alexander Hoffmann , Xiaotao Li
المصدر:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
بيانات النشر:
Nature Portfolio, 2016.
سنة النشر:
2016
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
REGγ is a component of ubiquitin-independent 20S proteasome that targets many regulatory proteins for degradation. Here the authors show that REGγ is induced in DSS colitis and promotes degradation of IκBɛ, and that REGγ-deficient mice have less NFκB activation and are more resistant to the disease.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/ncomms10761
URL الوصول:
https://doaj.org/article/815ed3c7811843c397e9095adc1ff9cf
رقم الأكسشن:
edsdoj.815ed3c7811843c397e9095adc1ff9cf
قاعدة البيانات:
Directory of Open Access Journals