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Establishing an invertebrate Galleria mellonella greater wax moth larval model of Neisseria gonorrhoeae infection

التفاصيل البيبلوغرافية
العنوان: Establishing an invertebrate Galleria mellonella greater wax moth larval model of Neisseria gonorrhoeae infection
المؤلفون: Aiste Dijokaite, Maria Victoria Humbert, Emma Borkowski, Roberto M La Ragione, Myron Christodoulides
المصدر: Virulence, Vol 12, Iss 1, Pp 1900-1920 (2021)
بيانات النشر: Taylor & Francis Group, 2021.
سنة النشر: 2021
المجموعة: LCC:Infectious and parasitic diseases
مصطلحات موضوعية: neisseria gonorrhoeae, galleria mellonella, infection, histopathology, Infectious and parasitic diseases, RC109-216
الوصف: Neisseria gonorrhoeae (gonococcus) causes the human sexually transmitted disease gonorrhea. Studying gonococcal pathogenesis and developing new vaccines and therapies to combat the increasing prevalence of multi-antibiotic resistant bacteria has made use of many ex vivo models based on human cells and tissues, and in vivo vertebrate models, for example, rodent, pig and human. The focus of the current study was to examine the utility of the invertebrate greater wax moth Galleria mellonella as an in vivo model of gonococcal infection. We observed that a threshold of ~106 – 107 gonococci/larva was required to kill >50% of larvae (P 0.05) than Pseudomonas aeruginosa. Larvae primed with nontoxic doses of gonococci were more susceptible to subsequent challenge with homologous and heterologous bacteria, and larval survival was significantly reduced (P 0.05).
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2150-5594
2150-5608
21505594
Relation: https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608
DOI: 10.1080/21505594.2021.1950269
URL الوصول: https://doaj.org/article/817fadf43d5d4f45a543487c38fa7eec
رقم الأكسشن: edsdoj.817fadf43d5d4f45a543487c38fa7eec
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21505594
21505608
DOI:10.1080/21505594.2021.1950269